PMID- 22007877
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20120213
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Linking)
VI  - 125
IP  - 3
DP  - 2012 Mar
TI  - Neural correlates of self-reflection in post-traumatic stress disorder.
PG  - 238-46
LID - 10.1111/j.1600-0447.2011.01773.x [doi]
AB  - OBJECTIVE: Disturbances in self-referential processing (SRP) are increasingly 
      recognized in post-traumatic stress disorder (PTSD). In healthy adults, SRP tasks 
      engage the medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC) 
      brain regions that have shown altered function in PTSD. We hypothesized that 
      individuals with PTSD would differ from controls in functional activation of the 
      MPFC and PCC during SRP. METHOD: We compared neural activation in healthy 
      controls (n = 15) and participants with PTSD (n = 20) during a SRP task, using 
      fMRI at 4.0T. RESULTS: Controls made faster responses to the self-relevance of 
      personal characteristics than to the accuracy of general facts, whereas response 
      times did not differ between these conditions in PTSD. Controls also demonstrated 
      greater MPFC (dorsal and ventral) and PCC response when considering the 
      self-relevance of personal characteristics in comparison with the accuracy of 
      general facts. Individuals with PTSD demonstrated less MPFC response than did 
      healthy controls for the contrast of self-relevance of personal characteristics 
      relative to general facts. CONCLUSIONS: These results implicate MPFC in SRP 
      disturbances associated with PTSD. These findings are relevant to current 
      proposals for including symptoms of negative self-referential cognition and 
      identity-existential disturbance as diagnostically relevant to PTSD.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Bluhm, R L
AU  - Bluhm RL
AD  - Department of Philosophy and Religious Studies, Old Dominion University, Norfolk, 
      VA, USA.
FAU - Frewen, P A
AU  - Frewen PA
FAU - Coupland, N C
AU  - Coupland NC
FAU - Densmore, M
AU  - Densmore M
FAU - Schore, A N
AU  - Schore AN
FAU - Lanius, R A
AU  - Lanius RA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Functional Neuroimaging
MH  - Gyrus Cinguli/pathology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/pathology/*physiopathology
MH  - Psychomotor Performance
MH  - Reaction Time
MH  - *Self Concept
MH  - *Self-Assessment
MH  - Stress Disorders, Post-Traumatic/pathology/*physiopathology
EDAT- 2011/10/20 06:00
MHDA- 2012/06/02 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - 10.1111/j.1600-0447.2011.01773.x [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2012 Mar;125(3):238-46. doi: 
      10.1111/j.1600-0447.2011.01773.x. Epub 2011 Oct 18.