PMID- 22008494
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20211020
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 16
IP  - 4
DP  - 2011 Oct
TI  - Changes in dipolar structure of cardiac magnetic field maps after ST elevation 
      myocardial infarction.
PG  - 379-87
LID - 10.1111/j.1542-474X.2011.00466.x [doi]
AB  - BACKGROUND: Pathological changes in cardiac electrophysiology have been 
      investigated in coronary artery disease using magnetocardiography. Aim of this 
      work was to examine the structure of cardiac magnetic field maps (MFM) during 
      ventricular depolarization and repolarization in patients with acute ST elevation 
      myocardial infarction (STEMI). METHODS: Magnetocardiograms were recorded in 39 
      healthy subjects and 97 patients who had been successfully revascularized after 
      STEMI. Using the Karhunen-Loeve transform, 12 eigenmaps were constructed for six 
      intervals within the QT interval of each subject's signal-averaged data. The 
      relative information content of the eigenmaps was compared between STEMI patients 
      and healthy subjects. RESULTS: Relative nondipolar content was between 0.03% and 
      0.52% higher in the STEMI group, (P < 0.001 for the repolarization intervals). 
      Information content of the first dipolar eigenmap in the STEMI group was reduced 
      by 2.6%-11.7% (P < 0.001 for the repolarization intervals). STT interval was best 
      able to discriminate between groups: area-under-the-curve for nondipolar content 
      was 85.8% (P < 0.001), for the first eigenmap 91.7% (P < 0.001). Severity of 
      infarction was reflected in lower STT interval map 1 content for patients with 
      anterior versus posterior infarction (83%+/- 11% vs. 87%+/- 10%, P < 0.05), with wall 
      motion disturbances (84%+/- 11% vs. 92%+/- 7%, P < 0.001) and with microvascular 
      obstruction (81%+/- 12% vs. 87%+/- 10%, P < 0.05). Regression analysis showed that 
      patients with lower ejection fraction tended to have less information content (P 
      < 0.001). CONCLUSION: STEMI is associated with a loss of spatial coherence during 
      repolarization, as quantified by principal component analysis of cardiac MFM.
CI  - (c)2011, Wiley Periodicals, Inc.
FAU - Van Leeuwen, Peter
AU  - Van Leeuwen P
AD  - Department of Biomagnetism, Gronemeyer Institute for Microtherapy, University 
      Witten/Herdecke, Universitatsstrasse 142, Bochum, Germany. 
      petervl@microtherapy.de
FAU - Hailer, Birgit
AU  - Hailer B
FAU - Beck, Alexander
AU  - Beck A
FAU - Eiling, Gregor
AU  - Eiling G
FAU - Gronemeyer, Dietrich
AU  - Gronemeyer D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Female
MH  - Humans
MH  - *Magnetic Fields
MH  - Magnetic Resonance Imaging, Cine
MH  - *Magnetocardiography
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology
MH  - Myocardium/*pathology
MH  - Principal Component Analysis
MH  - ROC Curve
PMC - PMC6932076
EDAT- 2011/10/20 06:00
MHDA- 2012/02/18 06:00
PMCR- 2011/10/18
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
PHST- 2011/10/18 00:00 [pmc-release]
AID - ANEC466 [pii]
AID - 10.1111/j.1542-474X.2011.00466.x [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2011 Oct;16(4):379-87. doi: 
      10.1111/j.1542-474X.2011.00466.x.