PMID- 22008768
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20191210
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15
IP  - 11
DP  - 2011 Nov
TI  - Improving the diagnosis of pulmonary tuberculosis in HIV-infected individuals in 
      Ho Chi Minh City, Viet Nam.
PG  - 1528-34, i
LID - 10.5588/ijtld.10.0777 [doi]
AB  - SETTING: District 6, An Hoa Clinic in Ho Chi Minh City (HCMC), Viet Nam. 
      OBJECTIVE: To evaluate the performance of various algorithms in tuberculosis (TB) 
      screening and diagnosis in a human immunodeficiency virus (HIV) infected 
      population in HCMC, Viet Nam. DESIGN: A cross-sectional study of 397 consecutive 
      HIV-infected patients seeking care at the An Hoa Clinic from August 2009 to June 
      2010. Data on participant demographics, clinical status, chest radiography (CXR) 
      and laboratory results were collected. A multiple logistic regression model was 
      developed to assess the association of covariates and pulmonary TB (PTB). 
      RESULTS: The prevalence of sputum culture-confirmed PTB, acid-fast bacilli (AFB) 
      positive TB, and multidrugresistant TB among the 397 HIV-infected patients was 
      respectively 7%, 2%, and 0.3%. Adjusted odds ratios for low CD4+ cell count, 
      positive sputum smear, and CXR to positive sputum culture were respectively 3.17, 
      32.04 and 4.28. Clinical findings alone had poor sensitivity, but combining CD4+ 
      cell count, AFB sputum smear and CXR had a more accurate diagnostic performance. 
      CONCLUSION: Results suggest that symptom screening had poor clinical performance, 
      and support the routine use of sputum culture to improve the detection of TB 
      disease in HIV-infected individuals in Viet Nam. However, when routine sputum 
      culture is not available, an algorithm combining CD4+ cell count, AFB sputum 
      smear and CXR is recommended for diagnosing PTB.
FAU - Nguyen, D T M
AU  - Nguyen DT
AD  - University of Texas School of Public Health, Houston, Texas 77030, USA. 
      ntmduc@yahoo.com
FAU - Hung, N Q
AU  - Hung NQ
FAU - Giang, L T
AU  - Giang LT
FAU - Dung, N H
AU  - Dung NH
FAU - Lan, N T N
AU  - Lan NT
FAU - Lan, N N
AU  - Lan NN
FAU - Yen, N T B
AU  - Yen NT
FAU - Bang, N D
AU  - Bang ND
FAU - Ngoc, D V
AU  - Ngoc DV
FAU - Trinh, L T T
AU  - Trinh LT
FAU - Beasley, R P
AU  - Beasley RP
FAU - Ford, C E
AU  - Ford CE
FAU - Hwang, L-Y
AU  - Hwang LY
FAU - Graviss, E A
AU  - Graviss EA
LA  - eng
GR  - AI36211/AI/NIAID NIH HHS/United States
GR  - D43TW007669/TW/FIC NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*diagnosis/epidemiology
MH  - Adult
MH  - Algorithms
MH  - CD4 Lymphocyte Count
MH  - Coinfection/*diagnosis/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*diagnosis/epidemiology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - *Mass Screening/methods
MH  - Mycobacterium tuberculosis/isolation & purification
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Radiography, Thoracic
MH  - Sputum/microbiology
MH  - Tuberculosis, Pulmonary/*diagnosis/epidemiology
MH  - *Urban Health Services/statistics & numerical data
MH  - Vietnam/epidemiology
EDAT- 2011/10/20 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - 10.5588/ijtld.10.0777 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Nov;15(11):1528-34, i. doi: 10.5588/ijtld.10.0777.