PMID- 22008851
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20120423
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 18
IP  - 5
DP  - 2012 May
TI  - Comparison of unrelated cord blood transplantation and HLA-mismatched unrelated 
      bone marrow transplantation for adults with leukemia.
PG  - 780-7
LID - 10.1016/j.bbmt.2011.10.008 [doi]
AB  - Recent advances in unrelated cord blood transplantation (UCBT) and 
      high-resolution typing of human leukocyte antigen (HLA) from an unrelated donor 
      have increased choices in alternative donor/stem cell source selection. We 
      assessed HLA-mismatched locus-specific comparison of the outcomes of 351 
      single-unit UCB and 1,028 unrelated bone marrow (UBM) adult recipients 16 years 
      old or older at the time of transplantation who received first stem cell 
      transplantation with myeloablative conditioning for acute leukemia or 
      myelodysplastic syndromes. With adjusted analyses, HLA 0 to 2 mismatched UCBT 
      showed similar overall mortality (relative risk [RR] = 0.85, 95% confidence 
      interval [CI], 0.68-1.06; P = .149) compared with that of 
      single-HLA-DRB1-mismatched UBMT. UCBT showed inferior neutrophil recovery (RR = 
      0.50, 95% CI, 0.42-0.60; P < .001), lower risk of acute graft-versus-host disease 
      (RR = 0.55, 95% CI, 0.42-0.72; P < .001), and lower risk of 
      transplantation-related mortality (RR = 0.68, 95% CI, 0.50-0.92; P = .011) 
      compared with single-HLA-DRB1-mismatched UBMT. No significant difference was 
      observed for risk of relapse (RR = 1.28, 95% CI, 0.93-1.76; P = .125). HLA 0 to 2 
      antigen-mismatched UCBT is a reasonable second alternative donor/stem cell source 
      with a survival outcome similar to that of single-HLA-DRB1-mismatched or other 7 
      of 8 UBMT.
CI  - Copyright (c) 2012 American Society for Blood and Marrow Transplantation. Published 
      by Elsevier Inc. All rights reserved.
FAU - Atsuta, Yoshiko
AU  - Atsuta Y
AD  - Department of HSCT Data Management/Biostatistics, Nagoya University Graduate 
      School of Medicine, Nagoya, Japan. y-atsuta@med.nagoya-u.ac.jp
FAU - Morishima, Yasuo
AU  - Morishima Y
FAU - Suzuki, Ritsuro
AU  - Suzuki R
FAU - Nagamura-Inoue, Tokiko
AU  - Nagamura-Inoue T
FAU - Taniguchi, Shuichi
AU  - Taniguchi S
FAU - Takahashi, Satoshi
AU  - Takahashi S
FAU - Kai, Shunro
AU  - Kai S
FAU - Sakamaki, Hisashi
AU  - Sakamaki H
FAU - Kouzai, Yasushi
AU  - Kouzai Y
FAU - Kobayashi, Naoki
AU  - Kobayashi N
FAU - Fukuda, Takahiro
AU  - Fukuda T
FAU - Azuma, Hiroshi
AU  - Azuma H
FAU - Takanashi, Minoko
AU  - Takanashi M
FAU - Mori, Takehiko
AU  - Mori T
FAU - Tsuchida, Masahiro
AU  - Tsuchida M
FAU - Kawase, Takakazu
AU  - Kawase T
FAU - Kawa, Keisei
AU  - Kawa K
FAU - Kodera, Yoshihisa
AU  - Kodera Y
FAU - Kato, Shunichi
AU  - Kato S
CN  - Japan Marrow Donor Program and Japan Cord Blood Bank Network
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/administration & dosage/therapeutic use
MH  - Bone Marrow Transplantation
MH  - *Cord Blood Stem Cell Transplantation
MH  - Disease-Free Survival
MH  - Female
MH  - Graft vs Host Disease/prevention & control
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia/immunology/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/immunology/mortality/*therapy
MH  - Recurrence
MH  - Risk Factors
MH  - *Transplantation Conditioning
MH  - Unrelated Donors
EDAT- 2011/10/20 06:00
MHDA- 2013/05/04 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/07/20 00:00 [received]
PHST- 2011/10/09 00:00 [accepted]
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - S1083-8791(11)00411-3 [pii]
AID - 10.1016/j.bbmt.2011.10.008 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2012 May;18(5):780-7. doi: 
      10.1016/j.bbmt.2011.10.008. Epub 2011 Oct 18.