PMID- 22010181
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20211020
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 103
IP  - 21
DP  - 2011 Nov 2
TI  - Prediagnostic plasma IgE levels and risk of adult glioma in four prospective 
      cohort studies.
PG  - 1588-95
LID - 10.1093/jnci/djr361 [doi]
AB  - BACKGROUND: Increased levels of serum immunoglobulin E (IgE) because of allergies 
      have been inversely associated with risk of glioma in observational studies. 
      Despite consistency across studies examining history of allergies and glioma, 
      questions remain as to whether those are causal associations. An inverse 
      association between serum IgE and risk of glioma was reported in a large 
      case-control study, but reverse causality and treatment effects remain potential 
      explanations for those findings. METHODS: We combined data from four prospective 
      cohort studies and used a nested case-control design to examine the association 
      between allergy and glioma. We included glioma case subjects who were confirmed 
      from medical or pathology records or from death certificates, and with 
      prediagnostic blood available. We matched three control subjects per case 
      subject, and the final numbers for analyses were 169 case subjects and 520 
      control subjects. Total IgE, food allergen-specific IgE, and respiratory 
      allergen-specific IgE levels were measured using a highly sensitive fluorescent 
      assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using 
      conditional logistic regression analysis. Stratified analyses were conducted by 
      age and birth cohorts. RESULTS: Borderline elevated total IgE levels (25-100 
      kU/L) showed a statistically significant inverse association with glioma (OR = 
      0.63, 95% CI = 0.42 to 0.93), but no association was noted between elevated IgE 
      (>100 kU/L) and glioma (OR = 0.98, 95% CI = 0.61 to 1.56) compared with 
      clinically normal IgE levels (<25 kU/L). The association between glioma and total 
      IgE was consistent for both men and women. Non-statistically significant inverse 
      associations were noted for elevated IgE levels among individuals born before 
      year 1930 (OR = 0.67, 95% CI = 0.34 to 1.34) and when restricting analyses to 
      highly fatal (deceased within 2 years of diagnosis) glioma case subjects (OR = 
      0.64, 95% CI = 0.34 to 1.19) compared with individuals with clinically normal IgE 
      levels. No associations were observed for either food allergen-specific or 
      respiratory allergen-specific IgE levels. CONCLUSIONS: Overall, our prospective 
      findings are consistent with recent retrospective studies and support an 
      association between total IgE levels and glioma. However, this association 
      requires further elucidation.
FAU - Calboli, Federico C F
AU  - Calboli FC
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Faculty of 
      Medicine, Imperial College London, London, UK.
FAU - Cox, David G
AU  - Cox DG
FAU - Buring, Julie E
AU  - Buring JE
FAU - Gaziano, J Michael
AU  - Gaziano JM
FAU - Ma, Jing
AU  - Ma J
FAU - Stampfer, Meir
AU  - Stampfer M
FAU - Willett, Walter C
AU  - Willett WC
FAU - Tworoger, Shelley S
AU  - Tworoger SS
FAU - Hunter, David J
AU  - Hunter DJ
FAU - Camargo, Carlos A Jr
AU  - Camargo CA Jr
FAU - Michaud, Dominique S
AU  - Michaud DS
LA  - eng
GR  - R01 CA047988/CA/NCI NIH HHS/United States
GR  - P01 CA087969/CA/NCI NIH HHS/United States
GR  - R01 CA114205/CA/NCI NIH HHS/United States
GR  - P01 CA055075/CA/NCI NIH HHS/United States
GR  - R01 CA097193/CA/NCI NIH HHS/United States
GR  - R01 HL043851/HL/NHLBI NIH HHS/United States
GR  - P01 CA097193/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111018
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - J Natl Cancer Inst. 2011 Nov 2;103(21):1562-3. PMID: 22010179
MH  - Adult
MH  - Aged
MH  - Allergens/*immunology
MH  - Asthma/complications
MH  - Brain Neoplasms/*diagnosis/*immunology
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Female
MH  - Glioma/*diagnosis/*immunology
MH  - Humans
MH  - Hypersensitivity/*complications/immunology
MH  - Immunoglobulin E/*blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prospective Studies
MH  - Research Design
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
PMC - PMC3206038
EDAT- 2011/10/20 06:00
MHDA- 2011/12/21 06:00
PMCR- 2012/11/02
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
PHST- 2012/11/02 00:00 [pmc-release]
AID - djr361 [pii]
AID - 10.1093/jnci/djr361 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2011 Nov 2;103(21):1588-95. doi: 10.1093/jnci/djr361. Epub 
      2011 Oct 18.