PMID- 22012451
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20190608
IS  - 1678-9946 (Electronic)
IS  - 0036-4665 (Linking)
VI  - 53
IP  - 5
DP  - 2011 Sep-Oct
TI  - Effect of bioactive compounds extracted from euphorbious plants on hematological 
      and biochemical parameters of Channa punctatus.
PG  - 259-63
LID - S0036-46652011000500004 [pii]
AB  - Channa punctatus was exposed to four different concentrations of Rutin, Taraxerol 
      and Apigenin. Changes in some hematological parameters of Channa punctatus were 
      assessed to determine the influence of these compounds on test fish. Fish were 
      exposed to sublethal concentrations (80% of LC50 of 24h) of these compounds for 
      one week. Control fish were also administered for one week. Thereafter, blood 
      samples were obtained from the control and experimental fish. Blood was assayed 
      for selected hematological parameters (hematocrit, hemoglobin, red blood cell 
      count, white blood cell count total plasma protein and plasma glucose 
      concentration). The derived hematological indices of mean corpuscular hemoglobin 
      concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular 
      volume (MCV) were calculated. Sublethal concentrations of these compounds caused 
      a dose dependent decrease in hemoglobin values coupled with a decrease in 
      hematocrit values and red blood cell counts are an obvious indication of anemia. 
      The total white blood cell counts and the differential white blood cell counts 
      were decreased except for the lymphocytes, where there was a slight increase. 
      Plasma protein and glucose were also lower in exposed fish when compared with 
      control. The hematological indices MCH, MCHC, MCV were also lowered. The result 
      from this study reveals high mortality rate and deleterious consequences on the 
      health of fish subjected to acute exposure of Rutin, Taraxerol and Apigenin and 
      therefore, should not be used directly in aquaculture without having the proper 
      knowledge.
FAU - Shahi, Jaya
AU  - Shahi J
AD  - Department of Zoology, Natural Product Laboratory, DDU Gorakhpur University, 
      Gorakhpur, UP, India.
FAU - Singh, Ajay
AU  - Singh A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Inst Med Trop Sao Paulo
JT  - Revista do Instituto de Medicina Tropical de Sao Paulo
JID - 7507484
RN  - 5G06TVY3R7 (Rutin)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - 7V515PI7F6 (Apigenin)
RN  - A32778O852 (taraxerol)
SB  - IM
MH  - Animals
MH  - Apigenin/isolation & purification/*pharmacology
MH  - Erythrocyte Indices
MH  - Euphorbiaceae/*chemistry/classification
MH  - Lethal Dose 50
MH  - Oleanolic Acid/*analogs & derivatives/isolation & purification/pharmacology
MH  - Perciformes/*blood
MH  - Rutin/isolation & purification/*pharmacology
EDAT- 2011/10/21 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/21 06:00
PHST- 2010/11/10 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0036-46652011000500004 [pii]
AID - 10.1590/s0036-46652011000500004 [doi]
PST - ppublish
SO  - Rev Inst Med Trop Sao Paulo. 2011 Sep-Oct;53(5):259-63. doi: 
      10.1590/s0036-46652011000500004.