PMID- 22013562
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20170427
IS  - 1699-3993 (Print)
IS  - 1699-3993 (Linking)
VI  - 47
IP  - 7
DP  - 2011 Jul
TI  - Recombinant tissue-type plasminogen activators: "time matters".
PG  - 559-70
LID - 10.1358/dot.2011.47.7.1600191 [doi]
AB  - Although acute ST elevation myocardial infarction (STEMI) was described nearly a 
      century ago, it remains a major health problem not only in the U.S. but also 
      worldwide with more than three million people suffering STEMI every year. Primary 
      percutaneous coronary intervention (PPCI) is now the treatment of choice for the 
      management of patients with STEMI. In the 20th century, fibrinolytics were the 
      agents of choice for the management of patients with acute STEMI and they 
      continue to be utilized in centers where PPCI facilities are not readily 
      available. Large-scale trials were performed comparing streptokinase and new 
      agents such as the recombinant tissue-type plasminogen activators. This article 
      discusses the use of recombinant tissue plasminogen activators for the management 
      of patients with acute STEMI and the importance of restoring optimal timely 
      reperfusion of the myocardium.
CI  - Copyright 2011 Prous Science, S.A.U. or its licensors. All rights reserved.
FAU - Kunadian, V
AU  - Kunadian V
AD  - Institute of Cellular Medicine, Newcastle University and Cardiothoracic Centre, 
      Newcastle upon Tyne, UK.
FAU - Gibson, C M
AU  - Gibson CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Spain
TA  - Drugs Today (Barc)
JT  - Drugs of today (Barcelona, Spain : 1998)
JID - 101160518
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Electrocardiography
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Humans
MH  - Myocardial Infarction/drug therapy
MH  - Recombinant Proteins/therapeutic use
MH  - Stroke/drug therapy
MH  - Tissue Plasminogen Activator/pharmacology/*therapeutic use
EDAT- 2011/10/21 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 1600191 [pii]
AID - 10.1358/dot.2011.47.7.1600191 [doi]
PST - ppublish
SO  - Drugs Today (Barc). 2011 Jul;47(7):559-70. doi: 10.1358/dot.2011.47.7.1600191.