PMID- 22013928
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20111021
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 33
IP  - 10
DP  - 2011
TI  - Copeptin and its relation to arteriovenous fistula (AVF) type and NYHA class in 
      hemodialysis patients.
PG  - 929-34
LID - 10.3109/0886022X.2011.618904 [doi]
AB  - Copeptin is cosynthesized with vasopressin, also known as anti-diuretic hormone, 
      with similar plasma levels. In the past 2 years, copeptin has been studied as a 
      diagnostic and prognostic marker in infections and other diseases. In patients 
      with decompensated heart failure, copeptin was an accurate prognostic marker for 
      mortality. Cardiovascular disease is a major contributor to the mortality and 
      morbidity in chronic kidney disease. Creation of an arteriovenous fistula (AVF) 
      might contribute to the development or worsening of congestive heart failure 
      (CHF). The aim of the study was to assess associations between copeptin, New York 
      Heart Association (NYHA) class, and the location of the AVF in hemodialysis (HD) 
      patients. The cross-sectional study was performed on a cohort of 93 clinically 
      stable HD patients. Patients with proximal AVF tend to be older, with decreased 
      renal residual function and increased NYHA functional class. These patients were 
      also highly anemic, had more acidosis, and had increased high-sensitivity 
      C-reactive protein along with increased copeptin and NT-proBNP levels. These 
      changes were also associated with significant changes in all intra-cardiac 
      dimensions, including right ventricle, both atria, and intraventricular septum 
      and increase in end-systolic and end-diastolic left ventricular intra-cardiac 
      dimensions. In multiple logistic regression analysis, the only associate of 
      copeptin was NYHA functional class. Copeptin level in HD patients depends on 
      cardiac function and it might be involved in the pathophysiology of 
      cardiovascular disease in these patients. Proximal AVF creation might contribute 
      to the development or worsening of CHF in HD patients.
FAU - Malyszko, Jolanta
AU  - Malyszko J
AD  - Department of Nephrology and Transplantology, Medical University, Bialystok, 
      Poland. jolmal@poczta.onet.pl
FAU - Levin-Iaina, Nomy
AU  - Levin-Iaina N
FAU - Malyszko, Jacek S
AU  - Malyszko JS
FAU - Kozminski, Piotr
AU  - Kozminski P
FAU - Koc-Zorawska, Ewa
AU  - Koc-Zorawska E
FAU - Mysliwiec, Michal
AU  - Mysliwiec M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Glycopeptides)
RN  - 0 (copeptins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Arteriovenous Shunt, Surgical/adverse effects/classification
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glycopeptides/*blood
MH  - Heart Failure/*blood/complications/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
MH  - Renal Insufficiency/*blood/complications/*therapy
EDAT- 2011/10/22 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.3109/0886022X.2011.618904 [doi]
PST - ppublish
SO  - Ren Fail. 2011;33(10):929-34. doi: 10.3109/0886022X.2011.618904.