PMID- 22014489 OWN - NLM STAT- MEDLINE DCOM- 20111206 LR - 20220331 IS - 1873-1740 (Electronic) IS - 0033-0620 (Linking) VI - 54 IP - 3 DP - 2011 Nov-Dec TI - Late gadolinium enhancement CMR predicts adverse cardiovascular outcomes and mortality in patients with coronary artery disease: systematic review and meta-analysis. PG - 215-29 LID - 10.1016/j.pcad.2011.07.003 [doi] AB - Cardiovascular magnetic resonance (CMR) has a recognized role in diagnosing and monitoring coronary artery disease (CAD). Multiple studies have shown that CMR can predict adverse outcomes. We reviewed contemporary available literature to establish the role of CMR with late gadolinium enhancement (LGE) in predicting mortality and major adverse cardiac events (MACEs) in patients with CAD. Meta-analysis of available prospective studies showed that the presence of LGE increases the hazards of death by more than 4 times and of MACE by almost 4 times. The size of LGE (per gram or percent) increases the hazards of death and MACE by 4% and 5%, respectively. The presence and size of LGE predict mortality and MACE in CAD. Various parameters derived from LGE images enhance the predictive value. Large randomized controlled trials are needed to establish the actual value of LGE and other derived parameters in the wider population. CI - Copyright (c) 2011 Elsevier Inc. All rights reserved. FAU - Zemrak, Filip AU - Zemrak F AD - Centre for Advanced Cardiovascular Imaging, William Harvey Research Institute, Queen Mary, University of London, Barts, UK. FAU - Petersen, Steffen E AU - Petersen SE LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review PL - United States TA - Prog Cardiovasc Dis JT - Progress in cardiovascular diseases JID - 0376442 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Cardiovascular Diseases/*etiology/mortality MH - *Contrast Media MH - Coronary Artery Disease/complications/*diagnosis/mortality MH - *Gadolinium MH - Humans MH - *Magnetic Resonance Imaging MH - Predictive Value of Tests MH - Prognosis MH - Risk Assessment MH - Risk Factors MH - Severity of Illness Index EDAT- 2011/10/22 06:00 MHDA- 2011/12/13 00:00 CRDT- 2011/10/22 06:00 PHST- 2011/10/22 06:00 [entrez] PHST- 2011/10/22 06:00 [pubmed] PHST- 2011/12/13 00:00 [medline] AID - S0033-0620(11)00136-8 [pii] AID - 10.1016/j.pcad.2011.07.003 [doi] PST - ppublish SO - Prog Cardiovasc Dis. 2011 Nov-Dec;54(3):215-29. doi: 10.1016/j.pcad.2011.07.003.