PMID- 22015481
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20161125
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 95
IP  - 1
DP  - 2012 Jan
TI  - Changes of the tubular markers in type 2 diabetes mellitus with glomerular 
      hyperfiltration.
PG  - 105-9
LID - 10.1016/j.diabres.2011.09.031 [doi]
AB  - AIM: To assess whether glomerular hyperfiltration (GHF) could result in renal 
      tubular damage in type 2 diabetes mellitus (T2DM) patients. METHODS: Reference 
      value of estimated glomerular filtration rate (eGFR) was determined in 248 
      healthy individuals based on serum CysC levels. GHF was defined as an eGFR 
      exceeding the sex-specific 97.5th percentile in non-diabetic individuals. In the 
      present study, 30 with GHF, 58 with norm-GFR T2DM, and 24 healthy controls were 
      recruited. Tubular markers, such as urinary N-acetyl-beta-D-glucosaminidase (NAG) 
      and kidney injury molecule 1 (KIM-1), as well as serum and urinary neutrophil 
      gelatinase-associated lipocalin (NGAL), were measured and compared. The 
      correlation of these markers with eGFR was analyzed in the GHF group. RESULTS: 
      The GHF group had higher urinary NGAL and KIM-1 levels but lower serum NGAL level 
      than the norm-GFR and control groups. Slightly decreased serum NGAL and increased 
      urinary NGAL levels were also noted in the norm-GFR group compared with those of 
      the controls. There was no statistical difference in the urinary NAG values among 
      the three groups. Correlation analysis showed that eGFR was positively related to 
      fasting blood glucose (FBG), HbA1c, urinary NGAL, and KIM-1, but negatively with 
      serum NGAL in the GHF group. CONCLUSION: Higher urinary tubular damage markers 
      were found in T2DM patients with GHF than the norm-GFR and control groups, 
      probably a direct proof that GHF is a deleterious factor for diabetic 
      nephropathy.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Fu, Wen-Jin
AU  - Fu WJ
AD  - Department of Laboratory, Affiliated Houjie Hospital, Guangdong Medical College, 
      Dongguan, Guangdong 523945, China.
FAU - Li, Bao-Liang
AU  - Li BL
FAU - Wang, Shao-Bo
AU  - Wang SB
FAU - Chen, Mei-Lian
AU  - Chen ML
FAU - Deng, Ren-Tang
AU  - Deng RT
FAU - Ye, Chang-Qin
AU  - Ye CQ
FAU - Liu, Liang
AU  - Liu L
FAU - Fang, Ai-Juan
AU  - Fang AJ
FAU - Xiong, Shi-Long
AU  - Xiong SL
FAU - Wen, Shu
AU  - Wen S
FAU - Tang, Hui-Hua
AU  - Tang HH
FAU - Chen, Zai-Xing
AU  - Chen ZX
FAU - Huang, Zhi-Hong
AU  - Huang ZH
FAU - Peng, Lan-Fen
AU  - Peng LF
FAU - Zheng, Lei
AU  - Zheng L
FAU - Wang, Qian
AU  - Wang Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111020
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Virus)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
SB  - IM
MH  - Acetylglucosaminidase/urine
MH  - Acute-Phase Proteins/urine
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood/urine
MH  - Blood Glucose/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology/urine
MH  - Diabetic Nephropathies/blood/*physiopathology/urine
MH  - Female
MH  - Glomerular Filtration Rate/*physiology
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Humans
MH  - Kidney Tubules/*physiopathology
MH  - Lipocalin-2
MH  - Lipocalins/blood/urine
MH  - Male
MH  - Membrane Glycoproteins/urine
MH  - Middle Aged
MH  - Proto-Oncogene Proteins/blood/urine
MH  - Receptors, Virus
EDAT- 2011/10/22 06:00
MHDA- 2012/07/12 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2011/09/20 00:00 [revised]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - S0168-8227(11)00533-X [pii]
AID - 10.1016/j.diabres.2011.09.031 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2012 Jan;95(1):105-9. doi: 
      10.1016/j.diabres.2011.09.031. Epub 2011 Oct 20.