PMID- 22015675
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20211020
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Feb
TI  - The management of thrombotic lesions in the cardiac catheterization laboratory.
PG  - 52-61
LID - 10.1007/s12265-011-9327-6 [doi]
AB  - Plaque rupture with superimposed thrombosis is the major mechanism of acute 
      coronary syndromes. Although angiography underestimates the presence of thrombi, 
      their detection is a poor prognostic indicator which is proportional to their 
      size. Although emergent percutaneous coronary intervention (PCI) in the setting 
      of ST elevation myocardial infarction (STEMI) and early PCI in the setting of 
      unstable angina and non-STEMI were shown to be preferred strategies, the presence 
      of angiographic thrombosis by virtue of causing micro and macro embolization can 
      reduce the benefit of the intervention. Antiplatelet therapy especially using 
      glycoprotein IIb/IIIa inhibitors reduces thrombus size, and improves myocardial 
      perfusion and ventricular function. Routine manual aspiration prior to PCI in 
      STEMI also improves myocardial flow and reduces distal embolization and improves 
      survival. Distal embolic protection devices and mechanical thrombectomy do not 
      have the same clinical benefits however, rheolytic thrombectomy may have a role 
      in large vessels with a large thrombi.
FAU - Matar, Fadi
AU  - Matar F
AD  - Tampa General Hospital, Tampa, FL 33609, USA. fmatar@me.com
FAU - Mroue, Jad
AU  - Mroue J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111021
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Acute Coronary Syndrome/diagnostic imaging/mortality/*therapy
MH  - Angioplasty, Balloon, Coronary
MH  - *Cardiac Catheterization/adverse effects/instrumentation/mortality
MH  - Coronary Angiography
MH  - Coronary Thrombosis/diagnostic imaging/mortality/*therapy
MH  - Embolic Protection Devices
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Myocardial Infarction/diagnostic imaging/mortality/*therapy
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Suction
MH  - Thrombectomy
MH  - Thrombolytic Therapy
MH  - Treatment Outcome
EDAT- 2011/10/22 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1007/s12265-011-9327-6 [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2012 Feb;5(1):52-61. doi: 10.1007/s12265-011-9327-6. 
      Epub 2011 Oct 21.