PMID- 22015727
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20220331
IS  - 1096-9896 (Electronic)
IS  - 0022-3417 (Linking)
VI  - 226
IP  - 1
DP  - 2012 Jan
TI  - Adenoid cystic carcinomas constitute a genomically distinct subgroup of 
      triple-negative and basal-like breast cancers.
PG  - 84-96
LID - 10.1002/path.2974 [doi]
AB  - Adenoid cystic carcinoma (AdCC) is a rare form of triple-negative and basal-like 
      breast cancer that has an indolent clinical behaviour. Four breast AdCCs were 
      recently shown to harbour the recurrent chromosomal translocation 
      t(6;9)(q22-23;p23-24), which leads to the formation of the MYB-NFIB fusion gene. 
      Our aims were (i) to determine the prevalence of the MYB-NFIB fusion gene in 
      AdCCs of the breast; (ii) to characterize the gene copy number aberrations found 
      in AdCCs; and (iii) to determine whether AdCCs are genomically distinct from 
      histological grade-matched or triple-negative and basal-like invasive ductal 
      carcinomas of no special type (IDC-NSTs). The presence of the MYB-NFIB fusion 
      gene was investigated in 13 AdCCs of the breast by fluorescence in situ 
      hybridization (FISH) and reverse transcriptase-PCR (RT-PCR), and MYB and BRCA1 
      RNA expression was determined by quantitative RT-PCR. Fourteen AdCCs, 14 
      histological grade-matched IDC-NSTs, and 14 IDC-NSTs of triple-negative and 
      basal-like phenotype were microdissected and subjected to high-resolution 
      microarray-based comparative genomic hybridization (aCGH). The MYB-NFIB fusion 
      gene was detected in all but one AdCC. aCGH analysis demonstrated a relatively 
      low number of copy number aberrations and a lack of recurrent amplifications in 
      breast AdCCs. Contrary to grade-matched IDC-NSTs, AdCCs lacked 1q gains and 16q 
      losses, and in contrast with basal-like IDC-NSTs, AdCCs displayed fewer gene copy 
      number aberrations and expressed MYB and BRCA1 at significantly higher levels. 
      Breast AdCCs constitute an entity distinct from grade-matched and triple-negative 
      and basal-like IDC-NSTs, emphasizing the importance of histological subtyping of 
      triple-negative and basal-like breast carcinomas.
CI  - Copyright (c) 2011 Pathological Society of Great Britain and Ireland. Published by 
      John Wiley & Sons, Ltd.
FAU - Wetterskog, Daniel
AU  - Wetterskog D
AD  - The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 
      London, UK.
FAU - Lopez-Garcia, Maria Angeles
AU  - Lopez-Garcia MA
FAU - Lambros, Maryou B
AU  - Lambros MB
FAU - A'Hern, Roger
AU  - A'Hern R
FAU - Geyer, Felipe C
AU  - Geyer FC
FAU - Milanezi, Fernanda
AU  - Milanezi F
FAU - Cabral, Maria C
AU  - Cabral MC
FAU - Natrajan, Rachael
AU  - Natrajan R
FAU - Gauthier, Arnaud
AU  - Gauthier A
FAU - Shiu, Kai-Keen
AU  - Shiu KK
FAU - Orr, Nicholas
AU  - Orr N
FAU - Shousha, Sami
AU  - Shousha S
FAU - Gatalica, Zoran
AU  - Gatalica Z
FAU - Mackay, Alan
AU  - Mackay A
FAU - Palacios, Jose
AU  - Palacios J
FAU - Reis-Filho, Jorge S
AU  - Reis-Filho JS
FAU - Weigelt, Britta
AU  - Weigelt B
LA  - eng
GR  - BREAST CANCER NOW RESEARCH CENTRE/BCN_/Breast Cancer Now/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111020
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (MYB-NFIB fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - EC 2.7.10.1 (Receptor, ErbB-3)
SB  - IM
MH  - Breast Neoplasms/*genetics/pathology
MH  - Carcinoma, Adenoid Cystic/*genetics/pathology
MH  - Carcinoma, Ductal, Breast/genetics/pathology
MH  - Female
MH  - Gene Dosage
MH  - Gene Expression Profiling
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Microdissection
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Receptor, ErbB-3/biosynthesis/genetics
MH  - Receptors, Estrogen/biosynthesis/genetics
MH  - Receptors, Progesterone/biosynthesis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tissue Array Analysis
EDAT- 2011/10/22 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2011/07/17 00:00 [revised]
PHST- 2011/07/18 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 10.1002/path.2974 [doi]
PST - ppublish
SO  - J Pathol. 2012 Jan;226(1):84-96. doi: 10.1002/path.2974. Epub 2011 Oct 20.