PMID- 22015915
OWN - NLM
STAT- MEDLINE
DCOM- 20130802
LR  - 20211203
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 244
DP  - 2013 Jun
TI  - Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and 
      related focal cortical malformations.
PG  - 22-6
LID - S0014-4886(11)00360-8 [pii]
LID - 10.1016/j.expneurol.2011.10.002 [doi]
AB  - Focal cortical dysplasia (FCD) and other localized malformations of cortical 
      development represent common causes of intractable pediatric epilepsy. Insights 
      into the cellular and molecular pathogenesis of focal cortical malformations may 
      reveal information about associated mechanisms of epileptogenesis and suggest new 
      therapies for seizures caused by these developmental lesions. In animal models 
      and human studies of FCD and the related disease of Tuberous Sclerosis Complex 
      (TSC), the mammalian target of rapamycin (mTOR) pathway has been implicated in 
      mediating cellular and molecular changes leading to the formation of the cortical 
      malformations and the expression of epilepsy. The use of mTOR inhibitors may 
      represent a rational therapeutic strategy for treating or even preventing 
      epilepsy due to FCD and TSC.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Wong, Michael
AU  - Wong M
AD  - Department of Neurology and the Hope Center for Neurological Disorders, 
      Washington University School of Medicine, St. Louis, MO 63110, USA. 
      wong_m@wustl.edu
LA  - eng
GR  - R01 NS056872/NS/NINDS NIH HHS/United States
GR  - R01 NS056872-06/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20111008
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Malformations of Cortical Development/*metabolism/pathology
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Tuberous Sclerosis/*metabolism/pathology
PMC - PMC3265661
MID - NIHMS331571
EDAT- 2011/10/22 06:00
MHDA- 2013/08/03 06:00
PMCR- 2014/06/01
CRDT- 2011/10/22 06:00
PHST- 2011/05/19 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2013/08/03 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - S0014-4886(11)00360-8 [pii]
AID - 10.1016/j.expneurol.2011.10.002 [doi]
PST - ppublish
SO  - Exp Neurol. 2013 Jun;244:22-6. doi: 10.1016/j.expneurol.2011.10.002. Epub 2011 
      Oct 8.