PMID- 22016823
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220408
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 1
IP  - 6
DP  - 2011
TI  - Menin represses tumorigenesis via repressing cell proliferation.
PG  - 726-39
AB  - Multiple endocrine neoplasia type 1 (MEN1) results from mutations in the tumor 
      suppressor gene, MEN1, which encodes nuclear protein menin. Menin is important 
      for suppressing tumorigenesis in various endocrine and certain non-endocrine 
      tissues. Although menin suppresses MEN1 through a variety of mechanisms including 
      regulating apoptosis and DNA repair, the role of menin in regulating cell 
      proliferation is one of the best-studied functions. Here, we focus on reviewing 
      various mechanisms underlying menin-mediated inhibition of cell proliferation. 
      Menin inhibits cell proliferation to repress MEN1 through multiple mechanisms. 1) 
      Menin interacts with various histonemodifying enzymes, such as MLL, EZH2 and 
      HDACs, to affect gene transcription, leading to repression of cell proliferation. 
      2) Menin also interacts with various transcription factors, such as JunD, NF-kappaB, 
      PPARgamma and VDR, to induce or suppress gene transcription. As these various 
      transcription factors are known to regulate cell proliferation, their interaction 
      with menin may be relevant to menin's role in inhibiting cell proliferation. 3) 
      Menin inhibits cell proliferation via TGF-beta signaling and Wnt/beta-catenin signaling 
      pathways. 4) Menin represses certain pro-proliferative factors involved in 
      endocrine tumors such as IGFBP-2, IGF2 and PTHrP to repress cell proliferation. 
      5) Menin affects cell cycle progression to inhibit cell proliferation. This 
      review is helpful in our understanding of the comprehensive mechanisms whereby 
      menin represses MEN1 through inhibiting cell proliferation.
FAU - Wu, Ting
AU  - Wu T
FAU - Hua, Xianxin
AU  - Hua X
LA  - eng
GR  - R01 CA113962/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20110516
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC3195934
OTO - NOTNLM
OT  - Menin
OT  - cell cycle
OT  - cell proliferation
OT  - epigenetics
OT  - gene transcription
EDAT- 2011/10/22 06:00
MHDA- 2011/10/22 06:01
PMCR- 2011/05/16
CRDT- 2011/10/22 06:00
PHST- 2011/04/20 00:00 [received]
PHST- 2011/05/08 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2011/10/22 06:01 [medline]
PHST- 2011/05/16 00:00 [pmc-release]
PST - ppublish
SO  - Am J Cancer Res. 2011;1(6):726-39. Epub 2011 May 16.