PMID- 22017684
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20221214
IS  - 1545-4304 (Electronic)
IS  - 0362-1642 (Linking)
VI  - 52
DP  - 2012
TI  - AMPK and mTOR in cellular energy homeostasis and drug targets.
PG  - 381-400
LID - 10.1146/annurev-pharmtox-010611-134537 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a central controller of cell growth 
      and proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and 
      mTOR complex 2 (mTORC2). mTORC1 is regulated by multiple signals such as growth 
      factors, amino acids, and cellular energy and regulates numerous essential 
      cellular processes including translation, transcription, and autophagy. The 
      AMP-activated protein kinase (AMPK) is a cellular energy sensor and signal 
      transducer that is regulated by a wide array of metabolic stresses. These two 
      pathways serve as a signaling nexus for regulating cellular metabolism, energy 
      homeostasis, and cell growth, and dysregulation of each pathway may contribute to 
      the development of metabolic disorders such as obesity, type 2 diabetes, and 
      cancer. This review focuses on our current understanding of the relationship 
      between AMPK and mTORC1 signaling and discusses their roles in cellular and 
      organismal energy homeostasis.
FAU - Inoki, Ken
AU  - Inoki K
AD  - Life Sciences Institute and Department of Molecular and Integrative Physiology, 
      University of Michigan, Ann Arbor, Michigan 48109, USA.
FAU - Kim, Joungmok
AU  - Kim J
FAU - Guan, Kun-Liang
AU  - Guan KL
LA  - eng
GR  - R01 CA108941/CA/NCI NIH HHS/United States
GR  - R01 DK124709/DK/NIDDK NIH HHS/United States
GR  - R01 GM051586/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20111017
PL  - United States
TA  - Annu Rev Pharmacol Toxicol
JT  - Annual review of pharmacology and toxicology
JID - 7607088
RN  - 0 (Amino Acids)
RN  - 0 (CRTC2 protein, human)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/genetics/*metabolism
MH  - Amino Acids/metabolism
MH  - Autophagy/physiology
MH  - Cell Proliferation
MH  - Drug Delivery Systems/*methods
MH  - Gene Expression Regulation
MH  - Homeostasis
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Multiprotein Complexes
MH  - Protein Biosynthesis/physiology
MH  - Proteins/genetics/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases
MH  - Transcription Factors/genetics/*metabolism
EDAT- 2011/10/25 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 10.1146/annurev-pharmtox-010611-134537 [doi]
PST - ppublish
SO  - Annu Rev Pharmacol Toxicol. 2012;52:381-400. doi: 
      10.1146/annurev-pharmtox-010611-134537. Epub 2011 Oct 17.