PMID- 22017685
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20131121
IS  - 1545-4304 (Electronic)
IS  - 0362-1642 (Linking)
VI  - 52
DP  - 2012
TI  - Drug hypersensitivity and human leukocyte antigens of the major 
      histocompatibility complex.
PG  - 401-31
LID - 10.1146/annurev-pharmtox-010611-134701 [doi]
AB  - The human leukocyte antigen (HLA) genes are the most polymorphic in the human 
      genome and are critical in regulating specific immunity, hence their historical 
      discovery as "immune response" genes. HLA allotypes are also implicated in 
      unwanted immune reactions, including drug hypersensitivity syndrome, in which 
      small therapeutic drugs interact with antigenic peptides to drive T cell 
      responses restricted by host HLA. Abacavir, allo-purinol, and carbamazepine are 
      three commonly used drugs that cause a T cell-mediated hypersensitivity that is 
      HLA linked, with each drug exhibiting striking specificity for presentation by 
      defined HLA allotypes. Recent findings have begun to unearth the mechanistic 
      basis for these HLA associations, and here we review recent advances in the field 
      of HLA-associated drug hypersensitivities.
FAU - Bharadwaj, Mandvi
AU  - Bharadwaj M
AD  - Department of Microbiology and Immunology, The University of Melbourne, 
      Parkville, Victoria 3010, Australia. mandvi@unimelb.edu.au
FAU - Illing, Patricia
AU  - Illing P
FAU - Theodossis, Alex
AU  - Theodossis A
FAU - Purcell, Anthony W
AU  - Purcell AW
FAU - Rossjohn, Jamie
AU  - Rossjohn J
FAU - McCluskey, James
AU  - McCluskey J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111017
PL  - United States
TA  - Annu Rev Pharmacol Toxicol
JT  - Annual review of pharmacology and toxicology
JID - 7607088
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA Antigens)
RN  - 33CM23913M (Carbamazepine)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Alleles
MH  - Allopurinol/adverse effects
MH  - Carbamazepine/adverse effects
MH  - Dideoxynucleosides/adverse effects
MH  - Drug Hypersensitivity/*genetics/*immunology
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Major Histocompatibility Complex/immunology
MH  - Pharmacogenetics
MH  - Polymorphism, Genetic
MH  - T-Lymphocytes/immunology/metabolism
EDAT- 2011/10/25 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 10.1146/annurev-pharmtox-010611-134701 [doi]
PST - ppublish
SO  - Annu Rev Pharmacol Toxicol. 2012;52:401-31. doi: 
      10.1146/annurev-pharmtox-010611-134701. Epub 2011 Oct 17.