PMID- 22018196
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 29
IP  - 5 Suppl 68
DP  - 2011 Sep-Oct
TI  - Toward safer treatment with glucocorticoids: via patient and rheumatologist 
      perspectives to recommendations on monitoring for adverse events.
PG  - S116-20
AB  - Glucocorticoids (GCs) play an important role in the treatment of rheumatic 
      diseases, but adverse events (AEs) are common, particularly at high doses. By 
      identifying perspectives of patients and rheumatologists on GC therapy reasons 
      for concerns about GC therapy and resistance to this treatment were evaluated. 
      Both patients and rheumatologists expressed concerns about AEs like osteoporosis, 
      diabetes and cardiovascular diseases. These concerns and the fact that many 
      GC-related AEs are - at least in part - preventable or treatable, underline the 
      importance of identification of AEs. The EULAR Task Force on Glucocorticoids 
      developed recommendations for monitoring of AEs during low-dose GC therapy in 
      daily practice and clinical trials, which were based on literature, perspectives 
      of patients and rheumatologists and issues such as clinical relevance. Safe 
      treatment with low-dose GCs in daily practice can be enhanced with use of a 
      limited set of recommendations. In clinical trials, monitoring of a more 
      comprehensive set of AEs is recommended, because this will also contribute to the 
      identification of the relevant AE-profile of GC therapy.
FAU - van der Goes, M C
AU  - van der Goes MC
AD  - Department of Rheumatology & Clinical Immunology, University Medical Center 
      Utrecht, Utrecht, the Netherlands. m.c.vandergoes@umcutrecht.nl
FAU - Jacobs, J W G
AU  - Jacobs JW
FAU - Bijlsma, J W J
AU  - Bijlsma JW
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20111022
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Drug Monitoring/*standards
MH  - Glucocorticoids/*administration & dosage/*adverse effects
MH  - Humans
MH  - Patients/psychology
MH  - Physicians/psychology
MH  - *Practice Guidelines as Topic
MH  - Rheumatic Diseases/*drug therapy
MH  - Rheumatology/*standards
EDAT- 2011/11/11 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/07/28 00:00 [received]
PHST- 2011/09/14 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - 5269 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2011 Sep-Oct;29(5 Suppl 68):S116-20. Epub 2011 Oct 22.