PMID- 22018609
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20111024
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 107
IP  - 5
DP  - 2011 Nov
TI  - SIT beyond respiratory diseases.
PG  - 395-400
LID - 10.1016/j.anai.2011.04.011 [doi]
AB  - OBJECTIVE: The goal was to assess the effectiveness of specific immunotherapy 
      (SIT) in reduction of symptoms and medication score in patients with 
      immunoglobulin E (IgE) mediated extrinsic form of atopic dermatitis (AD); and to 
      assess the effectiveness of oral immunotherapy (OIT) as "active" treatment to 
      achieving tolerance for food(s) in patients with IgE mediated food allergy. DATA 
      SOURCES: Computerized bibliographic searches of MEDLINE (1998-2010) were 
      supplemented by hand searches of reference lists. Studies were included if they 
      were double-blind randomized controlled trials comparing subcutaneous 
      immunotherapy (SCIT) or sublingual immunotherapy (SLIT) or OIT with placebo. 
      However uncontrolled studies and case reports were also included. STUDY 
      SELECTIONS: Thirty-two studies were analyzed. Because of the high heterogeneity 
      of the AD studied only results of 2 placebo controlled studies 1-SCIT and 1-SLIT 
      respectively were comparable. Among OIT studies: 4 carried out with control 
      groups were analyzed. RESULTS: From 36% to 92% of patients treated with OIT 
      reached tolerance to cow's milk or egg; a rate of 8% to 53% reached partial 
      tolerance. The patients had either clinical history of severe systemic reactions 
      to foods: anaphylaxis, or mild to moderate reactions. Regarding SIT for AD: 72% 
      of patients treated with house dust mite SCIT and 54% treated with SLIT had a 
      significant improvement of SCORAD-Index. CONCLUSIONS: This review found that OIT 
      with cow's milk or egg is effective in achieving full tolerance or partial 
      tolerance in the majority of patients with IgE mediated food allergy. SIT may 
      represent an additional therapeutic tool for the treatment of extrinsic AD in 
      properly selected patients.
CI  - Copyright (c) 2011 American College of Allergy. Published by Elsevier Inc. All 
      rights reserved.
FAU - Pajno, Giovanni B
AU  - Pajno GB
AD  - Department of Pediatrics, Allergy Unit, University of Messina, Italy. 
      Giovanni.Pajno@unime.it
FAU - Finegold, Ira
AU  - Finegold I
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110608
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 0 (Egg Proteins)
RN  - 0 (Milk Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/administration & dosage/adverse effects/immunology
MH  - Animals
MH  - Cattle
MH  - Dermatitis, Atopic/*drug therapy/*immunology/physiopathology
MH  - *Desensitization, Immunologic
MH  - Drug Administration Routes
MH  - Egg Proteins/administration & dosage/adverse effects/immunology
MH  - Food Hypersensitivity/*drug therapy/*immunology/physiopathology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/immunology
MH  - Milk Proteins/administration & dosage/adverse effects/immunology
MH  - Randomized Controlled Trials as Topic
EDAT- 2011/10/25 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/04/23 00:00 [revised]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1081-1206(11)00306-1 [pii]
AID - 10.1016/j.anai.2011.04.011 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2011 Nov;107(5):395-400. doi: 
      10.1016/j.anai.2011.04.011. Epub 2011 Jun 8.