PMID- 2201861
OWN - NLM
STAT- MEDLINE
DCOM- 19900926
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 47
IP  - 3
DP  - 1990
TI  - The function of protein carboxylmethyltransferase in eucaryotic cells.
PG  - 181-94
AB  - Protein carboxylmethyltransferase (PCM) is an enzyme whose function in eucaryotic 
      cells remains controversial. Early studies suggested that protein 
      carboxylmethylation subserved a regulatory, post-translational role in such 
      diverse processes as secretion, neuronal receptor function, chemotaxis, and 
      cellular differentiation. Later work strongly supported a totally unrelated role 
      for this enzyme, i.e., the repair of spontaneously altered aspartate residues in 
      cellular proteins. More recent evidence, however, suggests that a distinct, 
      membrane-associated PCM catalyzes the methylation of alpha-carboxyl groups of 
      C-terminal cysteines on discrete proteins. In view of these recent 
      investigations, the data supporting a regulatory role for PCM are critically 
      discussed and re-evaluated. There now appears to be compelling evidence that 
      PCM(s) subserves both repair and regulatory functions in eucaryotic cells, 
      catalyzing post-translational modifications of proteins involved in cell 
      division, hormonal secretion, calmodulin-associated events and the interaction of 
      guanyl nucleotide-linked proteins with the cell membrane.
FAU - Barten, D M
AU  - Barten DM
AD  - Department of Pediatrics, University of Minnesota Medical School, Minneapolis.
FAU - O'Dea, R F
AU  - O'Dea RF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - EC 2.1.1.- (Protein Methyltransferases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cells/*enzymology
MH  - Eukaryotic Cells/*enzymology
MH  - Protein Methyltransferases/*physiology
RF  - 119
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 0024-3205(90)90319-M [pii]
AID - 10.1016/0024-3205(90)90319-m [doi]
PST - ppublish
SO  - Life Sci. 1990;47(3):181-94. doi: 10.1016/0024-3205(90)90319-m.