PMID- 22018706
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20220309
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 153
IP  - 3
DP  - 2012 Mar
TI  - Foveal cone outer segment tips line and disruption artifacts in spectral-domain 
      optical coherence tomographic images of normal eyes.
PG  - 524-529.e1
LID - 10.1016/j.ajo.2011.08.021 [doi]
AB  - PURPOSE: To determine the incidence of a continuous cone outer segment tips 
      (COST) line at the fovea in spectral-domain optical coherence tomographic 
      (SD-OCT) images of normal eyes. DESIGN: Prospective, interventional case series. 
      METHODS: Forty-six right eyes of 46 normal individuals with visual acuities (VA) 
      >/=20/20 were studied. SD-OCT images were obtained with a Cirrus HD-OCT instrument 
      with both the standard 5-line raster and the high-definition (HD) 5-line raster 
      scan modes. Images with signal strengths weaker than 5 (on a scale from 0 to 10) 
      were excluded. The appearances of the COST line, photoreceptor inner 
      segment/outer segment (IS/OS) junction, and external limiting membrane (ELM) line 
      were determined in a masked way. RESULTS: The incidence of eyes with an intact 
      foveal COST line was about 95%, and the incidence was not significantly 
      associated with the age, sex, refractive error, signal strength, horizontal or 
      vertical scans, and the use of either the standard or HD scans. Fragmented COST 
      lines appeared to be attributable to blocking artifacts caused by a 
      hyperreflectivity at the foveal surface because the COST fragmentation had 
      corresponding fragmentation of the ELM and IS/OS junction lines. The correlation 
      between a fragmented COST line and the hyperreflectivity on the retinal surface 
      was significant for the vertical HD scans (P = .011) but not for the vertical 
      standard, horizontal standard, or horizontal HD scans. CONCLUSIONS: Commercial 
      SD-OCT instruments can detect the COST line. Fragmentations of the COST lines in 
      normal eyes are most likely artifacts caused by a parabolic reflection of a 
      surface hyperreflectivity of the foveal pit.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Rii, Tosho
AU  - Rii T
AD  - Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan.
FAU - Itoh, Yuji
AU  - Itoh Y
FAU - Inoue, Makoto
AU  - Inoue M
FAU - Hirakata, Akito
AU  - Hirakata A
LA  - eng
SI  - ClinicalTrials.gov/NCT01316003
PT  - Journal Article
DEP - 20111021
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Anatomy, Cross-Sectional
MH  - *Artifacts
MH  - Female
MH  - Fovea Centralis/*anatomy & histology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Cone Photoreceptor Cells/*cytology
MH  - Retinal Photoreceptor Cell Inner Segment
MH  - *Retinal Photoreceptor Cell Outer Segment
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2011/10/25 06:00
MHDA- 2012/04/21 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/04/14 00:00 [received]
PHST- 2011/08/05 00:00 [revised]
PHST- 2011/08/06 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - S0002-9394(11)00646-5 [pii]
AID - 10.1016/j.ajo.2011.08.021 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2012 Mar;153(3):524-529.e1. doi: 10.1016/j.ajo.2011.08.021. Epub 
      2011 Oct 21.