PMID- 22018906
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20220321
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 98
IP  - 2-3
DP  - 2012 Feb
TI  - Inter-session repeatability of cortical excitability measurements in patients 
      with epilepsy.
PG  - 182-6
LID - 10.1016/j.eplepsyres.2011.09.011 [doi]
AB  - PURPOSE: Previous studies have evaluated the inter-session variability of motor 
      thresholds (MT), short intracortical inhibition and intracortical facilitation 
      using paired pulse transcranial magnetic stimulation (TMS) in normal individuals. 
      Here we evaluate the reproducibility of a range of measures of cortical 
      excitability in patients with epilepsy. METHODS: Twenty-four drug naive patients 
      with newly diagnosed epilepsy (13 idiopathic generalised epilepsy [IGE], 11 focal 
      epilepsy) and seventeen non-epilepsy controls were studied. Motor threshold (MT) 
      at rest and recovery curves constructed using paired pulse stimulation at short 
      (2-15 ms) and long (50-400 ms) interstimulus intervals (ISIs) were analysed on 
      two separate occasions, 4-20 weeks apart. The Lin's concordance correlation 
      coefficient test was used to measure agreement between the two sessions. RESULTS: 
      Significant levels of agreement between the two sessions were observed at MT and 
      all the ISIs measured. This was highest in non-epilepsy controls. CONCLUSION: 
      Cortical excitability measures are repeatable over time in both patients with 
      epilepsy and healthy controls. Increased motor cortex excitability is a stable 
      feature in epilepsy without significant inter-session variability.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Badawy, Radwa A B
AU  - Badawy RA
AD  - Department of Neurology, Austin Health, Studley Road, Heidelberg, Victoria 3084, 
      Australia.
FAU - Jackson, Graeme D
AU  - Jackson GD
FAU - Berkovic, Samuel F
AU  - Berkovic SF
FAU - Macdonell, Richard A L
AU  - Macdonell RA
LA  - eng
PT  - Journal Article
DEP - 20111021
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biophysics
MH  - Cerebral Cortex/*physiopathology
MH  - Electric Stimulation
MH  - Electroencephalography
MH  - Electromyography
MH  - Epilepsy/*diagnosis
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neural Inhibition
MH  - Reproducibility of Results
MH  - *Seasons
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
EDAT- 2011/10/25 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/05/23 00:00 [received]
PHST- 2011/09/04 00:00 [revised]
PHST- 2011/09/17 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S0920-1211(11)00275-0 [pii]
AID - 10.1016/j.eplepsyres.2011.09.011 [doi]
PST - ppublish
SO  - Epilepsy Res. 2012 Feb;98(2-3):182-6. doi: 10.1016/j.eplepsyres.2011.09.011. Epub 
      2011 Oct 21.