PMID- 22020992
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 220
IP  - 4
DP  - 2012 Apr
TI  - The acute effects of 3,4-methylenedioxymethamphetamine and d-methamphetamine on 
      human cognitive functioning.
PG  - 799-807
LID - 10.1007/s00213-011-2532-9 [doi]
AB  - RATIONALE: This study investigated the acute (3-h) and 24-h post-dose cognitive 
      effects of oral 3,4-methylenedioxymethamphetamine (MDMA), d-methamphetamine, and 
      placebo in a within-subject double-blind laboratory-based study in order to 
      compare the effect of these two commonly used illicit drugs on a large number of 
      recreational drug users. METHODS: Sixty-one abstinent recreational users of 
      illicit drugs comprised the participant sample, with 33 females and 28 males, 
      mean age 25.45 years. The three testing sessions involved oral consumption of 
      100 mg MDMA, 0.42 mg/kg d-methamphetamine, or a matching placebo. The drug 
      administration was counter-balanced, double-blind, and medically supervised. 
      Cognitive performance was assessed during drug peak (3 h) and at 24 h post-dosing 
      time-points. Blood samples were also taken to quantify the levels of drug present 
      at the cognitive testing time-points. RESULTS: Blood concentrations of both 
      methamphetamine and MDMA at drug peak samples were consistent with levels 
      observed in previous studies. The major findings concern poorer performance in 
      the MDMA condition at peak concentration for the trail-making measures and an 
      index of working memory (trend level), and more accurate performance on a choice 
      reaction task within the methamphetamine condition. Most of the differences in 
      performance between the MDMA, methamphetamine, and placebo treatments diminished 
      by the 24-h testing time-point, although some performance improvements subsisted 
      for choice reaction time for the methamphetamine condition. CONCLUSIONS: Further 
      research into the acute effects of amphetamine preparations is necessary to 
      further quantify the acute disruption of aspects of human functioning crucial to 
      complex activities such as attention, selective memory, and psychomotor 
      performance.
FAU - Stough, Con
AU  - Stough C
AD  - Centre for Human Psychopharmacology, Swinburne University of Technology, 
      Hawthorn, VIC, 3122, Australia. cstough@gmail.com
FAU - King, Rebecca
AU  - King R
FAU - Papafotiou, Katherine
AU  - Papafotiou K
FAU - Swann, Phillip
AU  - Swann P
FAU - Ogden, Edward
AU  - Ogden E
FAU - Wesnes, Keith
AU  - Wesnes K
FAU - Downey, Luke A
AU  - Downey LA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111022
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Cognition/*drug effects/*physiology
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Methamphetamine/*administration & dosage
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Photic Stimulation/methods
MH  - Psychomotor Performance/drug effects/physiology
MH  - Reaction Time/drug effects/physiology
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/10/25 06:00
MHDA- 2012/12/27 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/05/09 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1007/s00213-011-2532-9 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2012 Apr;220(4):799-807. doi: 
      10.1007/s00213-011-2532-9. Epub 2011 Oct 22.