PMID- 22021702
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111024
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Linking)
VI  - 25
IP  - 6
DP  - 2011 Nov-Dec
TI  - Study of insulin resistance, TNF-alpha, total antioxidant capacity and lipid profile 
      in patients with chronic heart failure under exercise.
PG  - 1031-7
AB  - Gluco-metabolic syndrome, oxidative stress and inflammation are common in chronic 
      heart failure (CHF). Exercise training programmes are known to improve oxidative 
      status, insulin sensitivity and endothelial function. In this study, the effects 
      of walking on improving lipid and glucose metabolism in CHF patients, under 
      statin treatment, were investigated. Fasting glucose, serum insulin, tumor 
      necrosis factor-alpha (TNF-alpha), total antioxidant capacity (TAC), uric acid (UA), 
      total cholesterol, triglycerides, high-density lipoproteins (HDL), direct 
      low-density lipoproteins (LDL-dir), apolipoprotein-B, apolipoprotein-A1, and 
      lipoprotein-a (Lp(a)) were monitored. Insulin resistance was depicted by fasting 
      insulin resistance index (FIRI) (FIRI>/=2.94+/-1.41). HDL significantly increased 
      with walking and was positively correlated with the non-significant triglyceride 
      decrease and significant Lp(a) decrease. Significant correlations were found in 
      all CHF patients at baseline between FIRI and New York Heart Association (NYHA) 
      functional class, ejection fraction, HDL, triglycerides and TNF-alpha. All 
      non-diabetic CHF patients were characterized by insulin resistance. Serum insulin 
      and fasting glucose significantly decreased with walking, while decrease in FIRI 
      was positively associated with patients' adherence to the walking program. 
      Elevated uric acid and TNF-alpha levels also significantly decreased. In conclusion, 
      the present study demonstrated that moderate, unsupervised, everyday physical 
      activity was able to ameliorate the lipid and glycemic profile of CHF patients, 
      with simultaneous attenuation of inflammation and oxidative stress.
FAU - Tsarouhas, Konstantinos
AU  - Tsarouhas K
AD  - Cardiology Division, General Hospital of Karditsa, Terma Tavropou, 43100, 
      Karditsa, Greece. ktsarouhas14@yahoo.gr
FAU - Tsitsimpikou, Christina
AU  - Tsitsimpikou C
FAU - Haliassos, Alexander
AU  - Haliassos A
FAU - Georgoulias, Panagiotis
AU  - Georgoulias P
FAU - Koutsioras, Ioannis
AU  - Koutsioras I
FAU - Kouretas, Demetrios
AU  - Kouretas D
FAU - Kogias, John
AU  - Kogias J
FAU - Liosis, Ioannis
AU  - Liosis I
FAU - Rentoukas, Elias
AU  - Rentoukas E
FAU - Kyriakides, Zenon
AU  - Kyriakides Z
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Antioxidants)
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Aged
MH  - Antioxidants/*metabolism
MH  - Chronic Disease
MH  - *Exercise
MH  - Female
MH  - Heart Failure/*metabolism/physiopathology/therapy
MH  - Humans
MH  - *Insulin Resistance
MH  - *Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance
MH  - Tumor Necrosis Factors/*physiology
MH  - Walking
EDAT- 2011/10/25 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 25/6/1031 [pii]
PST - ppublish
SO  - In Vivo. 2011 Nov-Dec;25(6):1031-7.