PMID- 22022189
OWN - NLM
STAT- MEDLINE
DCOM- 20120215
LR  - 20211020
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 26
IP  - 10
DP  - 2011 Oct
TI  - Electrode position and the clinical outcome after bilateral subthalamic nucleus 
      stimulation.
PG  - 1344-55
LID - 10.3346/jkms.2011.26.10.1344 [doi]
AB  - We compared the surgical outcome with electrode positions after bilateral 
      subthalamic nucleus (STN) stimulation surgery for Parkinson's disease. 
      Fifty-seven patients treated with bilateral STN stimulations were included in 
      this study. Electrode positions were determined in the fused images of 
      preoperative MRI and postoperative CT taken at six months after surgery. The 
      patients were divided into three groups: group I, both electrodes in the STN; 
      group II, only one electrode in the STN; group III, neither electrode in the STN. 
      Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr stage, and 
      activities of daily living scores significantly improved at 6 and 12 months after 
      STN stimulation in both group I and II. The off-time UPDRS III speech subscore 
      significantly improved (1.6 +/- 0.7 at baseline vs 1.3 +/- 0.8 at 6 and 12 months, P 
      < 0.01) with least L-dopa equivalent daily dose (LEDD) (844.6 +/- 364.1 mg/day at 
      baseline; 279.4 +/- 274.6 mg/day at 6 months; and 276.0 +/- 301.6 mg/day at 12 
      months, P < 0.001) at 6 and 12 months after STN deep brain stimulation (DBS) in 
      the group I. Our findings suggest that the better symptom relief including speech 
      with a reduced LEDD is expected in the patients whose electrodes are accurately 
      positioned in both STN.
FAU - Paek, Sun Ha
AU  - Paek SH
AD  - Movement Disorder Center and Clinical Research Institute, Seoul National 
      University Hospital, Seoul, Korea.
FAU - Lee, Jee-Young
AU  - Lee JY
FAU - Kim, Han-Joon
AU  - Kim HJ
FAU - Kang, Daehee
AU  - Kang D
FAU - Lim, Yong Hoon
AU  - Lim YH
FAU - Kim, Mi Ryoung
AU  - Kim MR
FAU - Kim, Cheolyoung
AU  - Kim C
FAU - Jeon, Beom Seok
AU  - Jeon BS
FAU - Kim, Dong Gyu
AU  - Kim DG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111001
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Antiparkinson Agents)
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antiparkinson Agents/adverse effects/*therapeutic use
MH  - Combined Modality Therapy
MH  - *Deep Brain Stimulation/adverse effects/instrumentation/methods
MH  - *Electrodes, Implanted
MH  - Female
MH  - Humans
MH  - Levodopa/adverse effects/therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/drug therapy/*therapy
MH  - Severity of Illness Index
MH  - Subthalamic Nucleus/*physiology
MH  - Treatment Outcome
PMC - PMC3192348
OTO - NOTNLM
OT  - Bilateral STN Stimulation
OT  - Clinical Outcome
OT  - Electrode Position
OT  - Fused Images
OT  - Parkinson Disease
EDAT- 2011/10/25 06:00
MHDA- 2012/02/16 06:00
PMCR- 2011/10/01
CRDT- 2011/10/25 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/08/29 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/02/16 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - 10.3346/jkms.2011.26.10.1344 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2011 Oct;26(10):1344-55. doi: 10.3346/jkms.2011.26.10.1344. 
      Epub 2011 Oct 1.