PMID- 22022327
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Print)
IS  - 1738-5520 (Linking)
VI  - 41
IP  - 9
DP  - 2011 Sep
TI  - Changes of pulmonary pathology and gene expressions after simvastatin treatment 
      in the monocrotaline-induced pulmonary hypertension rat model.
PG  - 518-27
LID - 10.4070/kcj.2011.41.9.518 [doi]
AB  - BACKGROUND AND OBJECTIVES: Simvastatin's properties are suggestive of a potential 
      pathophysiologic role in pulmonary hypertension. The objectives of this study 
      were to investigate changes of pulmonary pathology and gene expressions, 
      including endothelin (ET)-1, endothelin receptor A (ERA), inducible nitric oxide 
      synthase (NOS2), endothelial nitric oxide synthase (NOS3), matrix 
      metalloproteinase (MMP) 2, tissue inhibitor of matrix metalloproteinases (TIMP) 
      and caspase 3, and to evaluate the effect of simvastatin on monocrotaline 
      (M)-induced pulmonary hypertension. MATERIALS AND METHODS: Six week old male 
      Sprague-Dawley rats were treated, as follows: control group, subcutaneous (sc) 
      injection of saline; M group, sc injection of M (60 mg/kg); and simvastatin 
      group, sc injection of M (60 mg/kg) plus 10 mg/kg/day simvastatin orally. 
      RESULTS: On day 28, right ventricular hypertrophy (RVH) significantly decreased 
      in the simvastatin group compared to the M group. Similarly, right ventricular 
      pressure significantly decreased in the simvastatin group on day 28. From day 7, 
      the ratio of medial thickening of the pulmonary artery was significantly 
      increased in the M group, but there was no significant change in the simvastatin 
      group. The number of muscular pulmonary arterioles was significantly reduced in 
      the simvastatin group. On day 5, gene expressions of ET-1, ERA, NOS2, NOS3, MMP 
      and TIMP significantly decreased in the simvastatin group. CONCLUSION: 
      Administration of simvastatin exerted weak inhibitory effects on RVH and on the 
      number of muscular pulmonary arterioles, during the development of M-induced 
      pulmonary hypertension in rats. Simvastatin decreased gene expressions on day 5.
FAU - Lee, Yun Hee
AU  - Lee YH
AD  - Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, 
      Korea.
FAU - Kim, Kwan Chang
AU  - Kim KC
FAU - Cho, Min-Sun
AU  - Cho MS
FAU - Hong, Young Mi
AU  - Hong YM
LA  - eng
PT  - Journal Article
DEP - 20110929
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
PMC - PMC3193043
OTO - NOTNLM
OT  - Gene expression
OT  - Hypertension, pulmonary
OT  - Monocrotaline
OT  - Simvastatin
COIS- The authors have no financial conflicts of interest.
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
PMCR- 2011/09/01
CRDT- 2011/10/25 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/01/03 00:00 [revised]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - 10.4070/kcj.2011.41.9.518 [doi]
PST - ppublish
SO  - Korean Circ J. 2011 Sep;41(9):518-27. doi: 10.4070/kcj.2011.41.9.518. Epub 2011 
      Sep 29.