PMID- 22026585
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20190918
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 177
IP  - 1
DP  - 2012 Jan
TI  - Preliminary FISH-based assessment of external dose for residents exposed on the 
      Techa River.
PG  - 84-91
AB  - This paper presents the results of a feasibility cytogenetic study using the 
      fluorescence in situ hybridization (FISH) translocation assay for residents of 
      villages located on the Techa River (Southern Urals, Russia) contaminated with 
      liquid radioactive wastes from the Mayak plutonium facility in 1949-1956. The 
      study was conducted with two groups of donors that differed in their main 
      pathways of exposure. The first group comprised 18 residents of the middle Techa 
      region who were exposed predominantly from ingestion of radionuclides (mostly 
      (89,90)Sr) via the river water and local foodstuffs. The second group included 20 
      residents of Metlino, the closest village to the site of releases, who were 
      exposed to external gamma radiation from the contaminated river bank and exposed 
      internally from dietary intake of radionuclides. A significant linear dependence 
      between the radiation-induced translocation frequency and individual red bone 
      marrow dose from incorporated (89,90)Sr, calculated with the Techa River 
      Dosimetry System (TRDS), was found in the first group of donors. This allowed us 
      to take the contribution of (89,90)Sr to the total radiation-induced 
      translocation frequency into account for the second group of donors and to 
      analyze translocations resulting from external gamma-ray exposure. Individual doses 
      from external exposure derived from the corrected translocation frequency for the 
      second group of donors (Metlino residents), using a linear dose-response 
      coefficient of 0.015 translocation/cell/Gy recommended by Edwards et al. in 2005, 
      were shown to vary up to 2.1 Gy, with an average value of 0.48 Gy, which was in 
      agreement with TRDS-based external dose estimates for Metlino residents.
FAU - Vozilova, A V
AU  - Vozilova AV
AD  - Urals Research Center for Radiation Medicine (URCRM), Chelyabinsk, Vorovsky str. 
      68A, 454076. vozilova@urcrm.ru
FAU - Shagina, N B
AU  - Shagina NB
FAU - Degteva, M O
AU  - Degteva MO
FAU - Edwards, A A
AU  - Edwards AA
FAU - Ainsbury, E A
AU  - Ainsbury EA
FAU - Moquet, J E
AU  - Moquet JE
FAU - Hone, P
AU  - Hone P
FAU - Lloyd, D C
AU  - Lloyd DC
FAU - Fomina, J N
AU  - Fomina JN
FAU - Darroudi, F
AU  - Darroudi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 0 (Strontium Radioisotopes)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Calibration
MH  - Environmental Exposure/*analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Laboratories
MH  - Male
MH  - Middle Aged
MH  - *Radiation Dosage
MH  - Radiation Monitoring/*methods
MH  - *Rivers
MH  - Russia
MH  - Strontium Radioisotopes/adverse effects/analysis
MH  - Translocation, Genetic/radiation effects
EDAT- 2011/10/27 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - 10.1667/RR2485.1 [pii]
AID - 10.1667/rr2485.1 [doi]
PST - ppublish
SO  - Radiat Res. 2012 Jan;177(1):84-91. doi: 10.1667/rr2485.1. Epub 2011 Oct 25.