PMID- 22028206
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20111222
IS  - 1861-471X (Electronic)
IS  - 1861-471X (Linking)
VI  - 7
IP  - 1
DP  - 2012 Jan 2
TI  - An anticoagulant activity system using nanoengineered autofluorescent heparin 
      nanotubes.
PG  - 127-32
LID - 10.1002/asia.201100425 [doi]
AB  - Heparin (HEP) and periodate-oxidized heparin (O-HEP) nanotubes were prepared by 
      combining the template method with a layer-by-layer (LbL) technique. The tubular 
      structure was obtained and characterized by scanning electron microscopy (SEM), 
      transmission electron microscopy (TEM), and confocal laser scanning microscopy 
      (CLSM). O-HEP is one of the HEP derivatives that contains anticoagulant activity 
      and preserves its ability for other effects. Chitosan (CHI) and O-HEP have been 
      used to fabricate nanotubes by covalent cross-linking Schiff base reactions. It 
      is demonstrated that the obtained nanotubes have the significant feature of 
      autofluorescence without the addition of any fluorescent dyes and they retain 
      their anticoagulation activity. Compared with O-HEP/CHI nanotubes, HEP/CHI 
      nanotubes show high anticoagulation activity and do not have autofluorescence. 
      Furthermore, this method could be extended to other copolysaccharide derivatives 
      for the preparation of autofluorescent nanomaterials.
CI  - Copyright (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Cui, Wei
AU  - Cui W
AD  - Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of 
      Chemistry, Chinese Academy of Sciences, Beijing, PR China.
FAU - Cui, Yue
AU  - Cui Y
FAU - Zhu, Pengli
AU  - Zhu P
FAU - Zhao, Jie
AU  - Zhao J
FAU - Su, Ying
AU  - Su Y
FAU - Yang, Yang
AU  - Yang Y
FAU - Li, Junbai
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111026
PL  - Germany
TA  - Chem Asian J
JT  - Chemistry, an Asian journal
JID - 101294643
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/chemical synthesis/chemistry/*pharmacology
MH  - Blood Coagulation/*drug effects
MH  - Blood Coagulation Tests
MH  - *Fluorescence
MH  - Heparin/chemical synthesis/chemistry/*pharmacology
MH  - Humans
MH  - Nanotechnology/*methods
MH  - Nanotubes/*chemistry
MH  - Particle Size
MH  - Reference Values
MH  - Surface Properties
EDAT- 2011/10/27 06:00
MHDA- 2012/04/21 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/05/01 00:00 [received]
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - 10.1002/asia.201100425 [doi]
PST - ppublish
SO  - Chem Asian J. 2012 Jan 2;7(1):127-32. doi: 10.1002/asia.201100425. Epub 2011 Oct 
      26.