PMID- 22028365
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20211020
IS  - 1469-9001 (Electronic)
IS  - 1355-8382 (Print)
IS  - 1355-8382 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Long noncoding RNAs are generated from the mitochondrial genome and regulated by 
      nuclear-encoded proteins.
PG  - 2085-93
LID - 10.1261/rna.029405.111 [doi]
AB  - Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to 
      date. By analysis of deep-sequencing data we have identified three lncRNAs 
      generated from the mitochondrial genome and confirmed their expression by 
      Northern blotting and strand-specific qRT-PCR. We show that the abundance of 
      these lncRNAs is comparable to their complementary mRNAs and that nuclear-encoded 
      mitochondrial proteins involved in RNA processing regulate their expression. We 
      also identify the 5' and 3' transcript ends of the three lncRNAs and show that 
      mitochondrial RNase P protein 1 (MRPP1) is important for the processing of these 
      transcripts. Finally, we show that mitochondrial lncRNAs form intermolecular 
      duplexes and that their abundance is cell- and tissue-specific, suggesting a 
      functional role in the regulation of mitochondrial gene expression.
FAU - Rackham, Oliver
AU  - Rackham O
AD  - Western Australian Institute for Medical Research and Centre for Medical 
      Research, The University of Western Australia, Perth, Western Australia, 
      Australia.
FAU - Shearwood, Anne-Marie J
AU  - Shearwood AM
FAU - Mercer, Tim R
AU  - Mercer TR
FAU - Davies, Stefan M K
AU  - Davies SM
FAU - Mattick, John S
AU  - Mattick JS
FAU - Filipovska, Aleksandra
AU  - Filipovska A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - United States
TA  - RNA
JT  - RNA (New York, N.Y.)
JID - 9509184
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (RNA, Untranslated)
RN  - EC 3.1.26.5 (Ribonuclease P)
SB  - IM
MH  - Base Sequence
MH  - Cell Nucleus/genetics
MH  - Gene Expression Regulation
MH  - *Genome, Mitochondrial
MH  - HeLa Cells
MH  - Humans
MH  - Mitochondria/genetics/metabolism
MH  - Mitochondrial Proteins/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Nucleic Acid Conformation
MH  - Organ Specificity/genetics
MH  - RNA Stability
MH  - RNA, Untranslated/genetics/*metabolism
MH  - Ribonuclease P/genetics/*metabolism
PMC - PMC3222122
EDAT- 2011/10/27 06:00
MHDA- 2012/01/20 06:00
PMCR- 2012/12/01
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - rna.029405.111 [pii]
AID - NA [pii]
AID - 10.1261/rna.029405.111 [doi]
PST - ppublish
SO  - RNA. 2011 Dec;17(12):2085-93. doi: 10.1261/rna.029405.111. Epub 2011 Oct 25.