PMID- 22032160
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120802
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 29
IP  - 6
DP  - 2011 Jun
TI  - [Determination of 7 nipagin ester preservatives in leather by ultra performance 
      liquid chromatography-tandem mass spectrometry coupled with gel permeation 
      chromatographic clean-up].
PG  - 501-6
AB  - A novel method has been developed for the rapid separation and determination of 7 
      nipagin ester preservatives in leather by ultra performance liquid 
      chromatography-tandem mass spectrometry (UPLC-MS/MS) coupled with gel permeation 
      chromatographic (GPC) clean-up. Nipagin ester preservatives in leather were 
      extracted by ultrasonic extraction with methanol. The extract was dried by a 
      rotavapor and purified by GPC, then redissolved in the solvent of methanol-water 
      (1 : 1, v/v). The chromatographic analysis was performed on an Acquity UPLC BEH 
      C18 column (50 mm x 2.1 mm, 1.7 microm) with a gradient elution of methanol and 
      water as the mobile phases. The analytes were detected by electrospray ionization 
      (ESI) tandem mass spectrometry with multiple reaction monitoring (MRM) in 
      negative ion mode. Good linearity (r > 0.99) was observed between 0.1 and 1.0 
      mg/L for all the analytes. The recoveries and relative standard deviations (RSDs) 
      were checked by spiking samples with the 7 nipagin ester preservatives at the 
      three levels of 0.5, 1.0 and 3.0 mg/kg. The average recoveries of the 7 nipagin 
      ester preservatives were from (79.44 +/- 5.67)% to (98.07 +/- 9.50)%. The 
      precision values expressed as RSD ranged from 4.24% to 14.00% (n = 6). The limits 
      of detection were 4 -12 microg/kg and the limits of quantification were 13.2 - 
      39.6 microg/kg for the analytes. The method is simple, rapid, sensitive and 
      accurate, and suitable for the quantitative determination and confirmation of 7 
      nipagin ester preservatives in leather.
FAU - Wu, Gang
AU  - Wu G
AD  - Zhejiang Academy of Science and Technology for Inspection & Quarantine, Hangzhou 
      310015, China. wug_hz@163.com
FAU - Zhao, Shanhong
AU  - Zhao S
FAU - Wu, Jianjian
AU  - Wu J
FAU - Dong, Suozhuai
AU  - Dong S
FAU - Guo, Fanglong
AU  - Guo F
FAU - Wang, Lijun
AU  - Wang L
FAU - Ye, Qingfu
AU  - Ye Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
EDAT- 2011/10/29 06:00
MHDA- 2011/10/29 06:01
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2011/10/29 06:01 [medline]
AID - 10.3724/sp.j.1123.2011.00501 [doi]
PST - ppublish
SO  - Se Pu. 2011 Jun;29(6):501-6. doi: 10.3724/sp.j.1123.2011.00501.