PMID- 22032165
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 29
IP  - 6
DP  - 2011 Jun
TI  - [Simultaneous determination of multi-veterinary drug residues in honey by solid 
      phase extraction-high performance liquid chromatography-tandem mass 
      spectrometry].
PG  - 535-42
AB  - A method of solid phase extraction-liquid chromatography-tandem mass spectrometry 
      (SPE-LC-MS/MS) for simultaneous determination of 54 drug residues (sulfonamides, 
      nitroimidazoles, quinolones, macrolides, lincosamides and praziquantel) in honey 
      was developed. The honey samples were diluted by phosphate buffer solution (pH 8) 
      followed by a further cleanup procedure with an Oasis (HLB) SPE column. The 
      detection was carried out by LC-MS/ MS, using positive-ion electrospray 
      ionization in multiple reaction monitoring (MRM) mode, with one precursor/two 
      product ion transitions for each compound. Isotope dilution internal standard 
      method or external standard method was used to determine the residue contents 
      with a good linear relationship (r > 0.992). The limits of quantification (LOQs, 
      S/N > 10) were 1.0 microg/kg for sulfonamides and nitroimidazoles, 2.0 microg/kg 
      for quinolones and lincosamides, 3.0 microg/kg for macrolides, and 0.3 kg/kg for 
      praziquantel. The recovery ranges were from 32.6% to 114% with the relative 
      standard deviations (RSDs) between 1.3% and 28.9%. As a screening method, the 
      developed procedure is suitable for the determination and confirmation of the 
      drug residues in honey samples.
FAU - Hou, Jianbo
AU  - Hou J
AD  - Technic Center of Zhejiang Entry-Exit Inspection and Quarantine Bureau, Hangzhou 
      310016, China.
FAU - Xie, Wen
AU  - Xie W
FAU - Chen, Xiaomei
AU  - Chen X
FAU - Xi, Junyang
AU  - Xi J
FAU - Qian, Yan
AU  - Qian Y
FAU - Wang, Feng
AU  - Wang F
FAU - Liu, Haishanz
AU  - Liu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Nitroimidazoles)
RN  - 0 (Quinolones)
RN  - 0 (Sulfonamides)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drug Residues/*analysis
MH  - Food Contamination/*analysis
MH  - Honey/*analysis
MH  - Nitroimidazoles/analysis
MH  - Quinolones/analysis
MH  - Solid Phase Extraction/methods
MH  - Sulfonamides/analysis
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2011/10/29 06:00
MHDA- 2012/08/03 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
AID - 10.3724/sp.j.1123.2011.00535 [doi]
PST - ppublish
SO  - Se Pu. 2011 Jun;29(6):535-42. doi: 10.3724/sp.j.1123.2011.00535.