PMID- 22033335
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20231120
IS  - 1476-5403 (Electronic)
IS  - 1350-9047 (Print)
IS  - 1350-9047 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells.
PG  - 96-106
LID - 10.1038/cdd.2011.134 [doi]
AB  - Dendritic cells (DCs) initiate immune responses by transporting antigens and 
      migrating to lymphoid tissues to initiate T-cell responses. DCs are located in 
      the mucosal surfaces that are involved in human immunodeficiency virus (HIV) 
      transmission and they are probably among the earliest targets of HIV-1 infection. 
      DCs have an important role in viral transmission and dissemination, and HIV-1 has 
      evolved different strategies to evade DC antiviral activity. High mobility group 
      box 1 (HMGB1) is a DNA-binding nuclear protein that can act as an alarmin, a 
      danger signal to alert the innate immune system for the initiation of host 
      defense. It is the prototypic damage-associated molecular pattern molecule, and 
      it can be secreted by innate cells, including DCs and natural killer (NK) cells. 
      The fate of DCs is dependent on a cognate interaction with NK cells, which 
      involves HMGB1 expressed at NK-DC synapse. HMGB1 is essential for DC maturation, 
      migration to lymphoid tissues and functional type-1 polarization of naive T 
      cells. This review highlights the latest advances in our understanding of the 
      impact of HIV on the interactions between HMGB1 and DCs, focusing on the 
      mechanisms of HMGB1-dependent viral dissemination and persistence in DCs, and 
      discussing the consequences on antiviral innate immunity, immune activation and 
      HIV pathogenesis.
FAU - Gougeon, M-L
AU  - Gougeon ML
AD  - Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology 
      Department, Institut Pasteur, Paris, France. marie-lise.gougeon@pasteur.fr
FAU - Melki, M-T
AU  - Melki MT
FAU - Saidi, H
AU  - Saidi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111028
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - 0 (HMGB1 Protein)
RN  - 0 (NF-kappa B)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/virology
MH  - HIV Infections/*immunology/*virology
MH  - HIV-1/*physiology
MH  - HMGB1 Protein/genetics/*metabolism
MH  - Humans
MH  - *Immunity, Innate
MH  - Killer Cells, Natural/immunology/virology
MH  - Mice
MH  - Myeloid Cells/immunology/virology
MH  - NF-kappa B/metabolism
MH  - Th1 Cells/immunology/virology
MH  - Toll-Like Receptor 4/metabolism
MH  - *Virus Latency
MH  - Virus Replication
PMC - PMC3252828
EDAT- 2011/10/29 06:00
MHDA- 2012/03/31 06:00
PMCR- 2013/01/01
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - cdd2011134 [pii]
AID - 10.1038/cdd.2011.134 [doi]
PST - ppublish
SO  - Cell Death Differ. 2012 Jan;19(1):96-106. doi: 10.1038/cdd.2011.134. Epub 2011 
      Oct 28.