PMID- 22033605
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120910
LR  - 20231105
IS  - 1294-8322 (Print)
IS  - 1294-8322 (Linking)
VI  - 3
IP  - 4
DP  - 2001 Dec
TI  - Brain mechanisms of hallucinogens and entactogens.
PG  - 265-79
AB  - This review focuses on recent brain imaging and behavioral studies of sensory 
      gating functions, which assess similarities between the effects of classic 
      hallucinogens (eg, psilocybin), dissociative anesthetics (eg, ketamine), and 
      entactogens (eg, 3,4-methylenedioxymethamphetamine [MDMA]) in humans. 
      Serotonergic hallucinogens and psychotomimetic anesthetics produce overlapping 
      psychotic syndromes associated with a marked activation of the prefrontal cortex 
      (hyperfrontality) and other overlapping changes in temporoparietal, striatal, and 
      thalamic regions, suggesting that both classes of drugs act upon a common final 
      pathway. Together with the observation that both hallucinogens and 
      N-methyl-oaspartate (NMDA) antagonists disrupt sensory gating in rats by acting 
      on 5-hydroxytryptamine (serotonin) 5-HT(2) receptors located in 
      cortico-striato-thalamic circuitry these findings suggest that disruption of 
      cortico-subcortical processing leading to sensory overload of the cortex is a 
      communality of these psychoses. In contrast to hallucinogens, the entactogen MDMA 
      produces an emotional state of positive mood, concomitant with an activation of 
      prefrontolimbiclparalimbic structures and a deactivation of amygdala and 
      thalamus.
FAU - Vollenweider, F X
AU  - Vollenweider FX
AD  - Psychiatric University Hospital Zurich, Clinical Research Unit and Heffter 
      Research Center Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dialogues Clin Neurosci
JT  - Dialogues in clinical neuroscience
JID - 101238198
PMC - PMC3181663
OTO - NOTNLM
OT  - behavioral study
OT  - MDMA
OT  - NMDA antagonist
OT  - entactogen
OT  - hallucinogen
OT  - ketamine brain imaging
OT  - psilocybin
EDAT- 2001/12/01 00:00
MHDA- 2001/12/01 00:01
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2001/12/01 00:00 [pubmed]
PHST- 2001/12/01 00:01 [medline]
PST - ppublish
SO  - Dialogues Clin Neurosci. 2001 Dec;3(4):265-79.