PMID- 22033702
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20240213
IS  - 1873-4626 (Electronic)
IS  - 1091-255X (Print)
IS  - 1091-255X (Linking)
VI  - 16
IP  - 1
DP  - 2012 Jan
TI  - How much pharyngeal exposure is "normal"? Normative data for laryngopharyngeal 
      reflux events using hypopharyngeal multichannel intraluminal impedance (HMII).
PG  - 16-24; discussion 24-5
LID - 10.1007/s11605-011-1741-1 [doi]
AB  - BACKGROUND: Laryngopharyngeal reflux (LPR) can cause atypical symptoms, asthma, 
      and pulmonary fibrosis. The aim of this study was to establish the normative data 
      for LPR using hypopharyngeal multichannel intraluminal impedance-pH (HMII). 
      METHODS: Asymptomatic subjects underwent endoscopy followed by 24-h HMII using a 
      specialized impedance catheter configured to detect LPR before and after a 2-week 
      course of proton pump inhibitors (PPI). Subjects were excluded if they had 
      esophageal pathology or a positive DeMeester score. A cohort of 24 LPR patients 
      who had a complete response to treatment was used for comparison with the 
      normative data. RESULTS: Forty subjects were enrolled. Thirty-four subjects 
      completed one, and 25 completed both HMII testing periods off and on PPI. There 
      was no difference in the total number of reflux events between off and on PPI [22 
      (8-32) and 24 (10-28), respectively, p = 0.89]. The 95th percentiles of LPR off 
      and on PPI were 0 and 1, respectively. All patients with treatment responsive LPR 
      had pre-treatment HMII values of LPR greater than the 95th percentile. 
      CONCLUSION: LPR events are rare in an asymptomatic population. One or more LPR 
      events should be considered abnormal in patients with LPR symptoms regardless of 
      whether there is a positive DeMeester score.
FAU - Hoppo, Toshitaka
AU  - Hoppo T
AD  - Division of Thoracic and Foregut Surgery, Department of Cardiothoracic Surgery, 
      University of Pittsburgh Medical Center, Shadyside Medical Center, Suite 715, 
      5200 Centre Avenue, Pittsburgh, PA 15232, USA.
FAU - Sanz, Alejandro F
AU  - Sanz AF
FAU - Nason, Katie S
AU  - Nason KS
FAU - Carroll, Thomas L
AU  - Carroll TL
FAU - Rosen, Clark
AU  - Rosen C
FAU - Normolle, Daniel P
AU  - Normolle DP
FAU - Shaheen, Nicholas J
AU  - Shaheen NJ
FAU - Luketich, James D
AU  - Luketich JD
FAU - Jobe, Blair A
AU  - Jobe BA
LA  - eng
GR  - K07 CA151613/CA/NCI NIH HHS/United States
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20111028
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Asymptomatic Diseases
MH  - Catheterization/instrumentation
MH  - Electric Impedance
MH  - Endoscopy/instrumentation
MH  - Esophagus/physiopathology
MH  - Female
MH  - Humans
MH  - Hypopharynx/*physiopathology
MH  - Laryngopharyngeal Reflux/*drug therapy/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Reference Values
MH  - Young Adult
PMC - PMC4091908
MID - NIHMS597537
EDAT- 2011/10/29 06:00
MHDA- 2012/05/05 06:00
PMCR- 2014/07/10
CRDT- 2011/10/29 06:00
PHST- 2011/05/16 00:00 [received]
PHST- 2011/10/13 00:00 [accepted]
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
PHST- 2014/07/10 00:00 [pmc-release]
AID - S1091-255X(23)03656-9 [pii]
AID - 10.1007/s11605-011-1741-1 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2012 Jan;16(1):16-24; discussion 24-5. doi: 
      10.1007/s11605-011-1741-1. Epub 2011 Oct 28.