PMID- 22034887
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211203
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 59
IP  - 3
DP  - 2011 Sep
TI  - Histopathological predictors of regional lymph node metastasis at the invasive 
      front in early colorectal cancer.
PG  - 470-81
LID - 10.1111/j.1365-2559.2011.03964.x [doi]
AB  - AIMS: In early colorectal cancer (ECC), prediction of lymph node (LN) metastasis 
      is vital for the decision of additional surgical treatment after endoscopic 
      mucosal/submucosal resection. The aim of this study was to determine the 
      relationship between LN metastasis and comprehensive histopathological findings 
      including the cancer microenvironment in ECC. METHODS AND RESULTS: Using 111 ECC 
      cases, including 36 cases with LN metastasis, histopathological observations and 
      immunohistochemistry for lymphatic vessel endothelial hyaluronan receptor-1 
      (LYVE-1), von Willebrand factor, matrix metalloproteinase-7 (MMP-7), CXC 
      chemokine ligand-12 (CXCL12) and angiopoietin-like-4 (ANGPTL4) were conducted. 
      Relationships between LN metastasis and growth pattern, status of muscularis 
      mucosae, depth of cancer invasion, overall histopathological type, 
      histopathological type at the invasive front, tumour budding, neutrophil 
      infiltration in cancer cells (NIC), fibrotic cancer-stroma type, Crohn's-like 
      lymphoid reaction, microscopic abscess formation and lymphatic invasion were 
      determined. In addition, the expression of MMP-7, CXCL12 and ANGPTL4 in cancer 
      cells at the invasive front were also considered in the context of LN metastasis. 
      By multivariate analysis, lymphatic invasion, NIC and MMP-7 expression at the 
      invasive front were independent predictors of LN metastasis. CONCLUSIONS: LN 
      metastasis is regulated not only by the characteristics of cancer cells but also 
      by microenvironmental factors of lymphatics and neutrophils, especially at the 
      invasive front.
CI  - (c) 2011 Blackwell Publishing Limited.
FAU - Akishima-Fukasawa, Yuri
AU  - Akishima-Fukasawa Y
AD  - Department of Pathology, Toho University School of Medicine, Tokyo, Japan. 
      yfukasawa@med.toho-u.ac.jp
FAU - Ishikawa, Yukio
AU  - Ishikawa Y
FAU - Akasaka, Yoshikiyo
AU  - Akasaka Y
FAU - Uzuki, Miwa
AU  - Uzuki M
FAU - Inomata, Naomi
AU  - Inomata N
FAU - Yokoo, Tomoko
AU  - Yokoo T
FAU - Ishii, Ryuga
AU  - Ishii R
FAU - Shimokawa, Reiko
AU  - Shimokawa R
FAU - Mukai, Kiyoshi
AU  - Mukai K
FAU - Kiguchi, Hideko
AU  - Kiguchi H
FAU - Suzuki, Koyu
AU  - Suzuki K
FAU - Fujiwara, Mieko
AU  - Fujiwara M
FAU - Ogata, Kentaro
AU  - Ogata K
FAU - Niino, Hitoshi
AU  - Niino H
FAU - Sugiura, Hitoshi
AU  - Sugiura H
FAU - Ichinose, Akihiro
AU  - Ichinose A
FAU - Kuroda, Yoshikazu
AU  - Kuroda Y
FAU - Kuroda, Daisuke
AU  - Kuroda D
FAU - Ishii, Toshiharu
AU  - Ishii T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (ANGPTL4 protein, human)
RN  - 0 (Angiopoietin-Like Protein 4)
RN  - 0 (Angiopoietins)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Chemokine CXCL12)
RN  - EC 3.4.24.23 (MMP7 protein, human)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
SB  - IM
MH  - Aged
MH  - Angiopoietin-Like Protein 4
MH  - Angiopoietins/biosynthesis
MH  - Biomarkers, Tumor/*analysis
MH  - Chemokine CXCL12/biosynthesis
MH  - Colorectal Neoplasms/immunology/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphatic Metastasis/immunology
MH  - Male
MH  - Matrix Metalloproteinase 7/biosynthesis
MH  - Middle Aged
MH  - Neoplasm Invasiveness/immunology
MH  - Neutrophil Infiltration/immunology
EDAT- 2011/11/01 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1111/j.1365-2559.2011.03964.x [doi]
PST - ppublish
SO  - Histopathology. 2011 Sep;59(3):470-81. doi: 10.1111/j.1365-2559.2011.03964.x.