PMID- 2203522
OWN - NLM
STAT- MEDLINE
DCOM- 19901009
LR  - 20120625
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 50
IP  - 18
DP  - 1990 Sep 15
TI  - Constitutive and induced expression of growth factors in normal and chronic phase 
      chronic myelogenous leukemia Ph1 bone marrow stroma.
PG  - 5801-5
AB  - Study of growth factor RNA levels in the stromal cells derived from the adherent 
      layer of long-term bone marrow culture demonstrated constitutive expression of 
      transforming growth factor beta 1 (TGF-beta 1) and macrophage colony-stimulating 
      factor. These cells did not express granulocyte colony-stimulating factor, 
      granulocyte-monocyte colony-stimulating factor, interleukin (IL) 1 alpha, IL-1 
      beta, IL-3, and IL-6. However, granulocyte colony-stimulating factor expression 
      could be induced by recombinant human IL-1 beta; while IL-6 could be induced by 
      both IL-1 beta and tumor necrosis factor-alpha. No differences could be detected 
      between adherent layers established from normal and benign phase Ph1 chronic 
      myelogenous leukemia bone marrow. The uninduced expression of TGF-beta 1, a 
      potent hematopoietic cell growth inhibitor, suggests that stromal cells play an 
      inherent role in regulating the proliferation of adjacent bone marrow 
      hematopoietic progenitor cells. However, a defect in stromal TGF-beta 1 
      production cannot account for the profoundly expanded myeloid compartment in 
      chronic phase chronic myelogenous leukemia. In contrast to the constitutive 
      expression of TGF-beta 1 and macrophage colony-stimulating factor, hematopoietic 
      growth factors are only expressed following a proper stimulation.
FAU - Wetzler, M
AU  - Wetzler M
AD  - Department of Clinical Immunology and Biological Therapy, M.D. Anderson Cancer 
      Center, Houston, Texas 77030.
FAU - Kurzrock, R
AU  - Kurzrock R
FAU - Taylor, K
AU  - Taylor K
FAU - Spitzer, G
AU  - Spitzer G
FAU - Kantarjian, H
AU  - Kantarjian H
FAU - Baiocchi, G
AU  - Baiocchi G
FAU - Ku, S
AU  - Ku S
FAU - Gutterman, J U
AU  - Gutterman JU
FAU - Talpaz, M
AU  - Talpaz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Biological Factors)
RN  - 0 (Colony-Stimulating Factors)
RN  - 0 (Cytokines)
RN  - 0 (Interleukins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 76057-06-2 (Transforming Growth Factors)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (BCR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-bcr)
SB  - IM
MH  - Biological Factors/genetics/pharmacology
MH  - Bone Marrow/*metabolism
MH  - Cells, Cultured
MH  - Colony-Stimulating Factors/*genetics
MH  - Cytokines
MH  - *Gene Expression
MH  - Gene Rearrangement
MH  - Humans
MH  - Interleukins/genetics
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*metabolism/pathology
MH  - Macrophage Colony-Stimulating Factor
MH  - *Protein-Tyrosine Kinases
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-bcr
MH  - RNA, Messenger/analysis
MH  - Transforming Growth Factors/*genetics
EDAT- 1990/09/15 00:00
MHDA- 1990/09/15 00:01
CRDT- 1990/09/15 00:00
PHST- 1990/09/15 00:00 [pubmed]
PHST- 1990/09/15 00:01 [medline]
PHST- 1990/09/15 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1990 Sep 15;50(18):5801-5.