PMID- 22035429
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20221207
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 39
IP  - 1
DP  - 2012 Feb
TI  - Allele frequencies of human leukocyte antigen-G in a Korean population.
PG  - 39-45
LID - 10.1111/j.1744-313X.2011.01053.x [doi]
AB  - The human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility 
      complex class I molecule with relatively limited polymorphism. The differences in 
      allele frequency according to ethnicity and country have not been studied enough, 
      so far. Therefore, fundamental data including allele frequencies and polymorphism 
      are needed for studies on immunological function of HLA-G in each population. We 
      investigated allele frequencies and 14-bp polymorphism of the HLA-G in Koreans. 
      HLA-G alleles and 14-bp polymorphisms were determined by sequence-based typing 
      analysis of exons 2-4 and polymerase chain reaction of exon 8 in 200 unrelated 
      individuals. Genotyping analysis identified eight different HLA-G alleles, which 
      indicates that the Korean population presents limited HLA-G allelic polymorphism. 
      HLA-G*01:01:01:01 and G*01:04:01 were frequent alleles (42.5% and 34.0%), and 
      allelic frequencies were similar to those of other Asian populations. The 14-bp 
      deletion alleles are higher (78%) in Koreans, although the frequencies of the 
      14-bp insertion/deletion polymorphism have been known to be nearly equal in many 
      Caucasian populations. HLA-G*01:01:08 was reported strong linkage disequilibrium 
      with the 14-bp deletion in a previous report; the same allele was accompanied 
      with 14-bp insertion in our study. There are a few studies investigating allele 
      frequencies, and most of them were studied before high-resolution method era. 
      This is the first study regarding HLA-G genotypes in Korean, which were 
      identified by high-resolution method. From this study, we identified HLA-G 
      frequencies of a Korean population and expect this study could help further 
      investigations for immunological and clinical implications of HLA-G.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Park, Y
AU  - Park Y
AD  - Department of Laboratory Medicine, Kwandong University College of Medicine, 
      Goyang, Korea.
FAU - Park, Y
AU  - Park Y
FAU - Kim, Y S
AU  - Kim YS
FAU - Kwon, O J
AU  - Kwon OJ
FAU - Kim, H-S
AU  - Kim HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111029
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-G Antigens)
SB  - IM
EIN - Int J Immunogenet. 2014 Dec;41(6):546
MH  - Alleles
MH  - Asian People/ethnology/genetics
MH  - Base Sequence
MH  - Exons
MH  - *Gene Frequency
MH  - *Genetics, Population
MH  - Genome, Human
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - INDEL Mutation
MH  - Linkage Disequilibrium
MH  - *Polymorphism, Genetic
EDAT- 2011/11/01 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1111/j.1744-313X.2011.01053.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2012 Feb;39(1):39-45. doi: 10.1111/j.1744-313X.2011.01053.x. 
      Epub 2011 Oct 29.