PMID- 22035445
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Oct 29
TI  - The clinical impact of late gadolinium enhancement in Takotsubo cardiomyopathy: 
      serial analysis of cardiovascular magnetic resonance images.
PG  - 67
LID - 10.1186/1532-429X-13-67 [doi]
AB  - BACKGROUND: Our study aimed to investigate both the clinical implications of late 
      gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) and the 
      relation of LGE to clinical findings in patients with Takotsubo cardiomyopathy 
      (TTC). METHODS: We evaluated 20 consecutive patients (2 men, 18 women; median 
      age, 77 years; interquartile range [IQR] 67-82 years) who were admitted to our 
      hospital with the diagnosis of TTC. CMR was performed within 1 week after 
      admission, and follow-up studies were conducted 1.5 and 6 months later. RESULTS: 
      In 8 patients, CMR imaging during the sub-acute phase revealed LGE in the area 
      matched with wall motion impairment. Cardiogenic shock was more frequently 
      observed in patients with LGE than in those without LGE (38% vs 0%, p = 0.049). 
      The patients with LGE needed a longer duration for ECG normalization and recovery 
      of wall motion than did those without LGE (median 205 days, IQR [152-363] vs 68 
      days, [43-145], p = 0.005; 15 days, [10-185] vs 7 days, [4-13], p = 0.030, 
      respectively). In 5 of these 8 patients, LGE disappeared within 45-180 days (170, 
      IQR [56-180]) of onset. The patients with LGE remaining in the chronic phase had 
      higher peak creatine kinase levels than did those without LGE (median 307 IU/L, 
      IQR [264-460] vs 202 IU/L, [120-218], p = 0.017). CONCLUSION: LGE by CMR in the 
      sub-acute phase may be associated with the severity and prolonged recovery to 
      normal of clinical findings in TTC.
FAU - Naruse, Yoshihisa
AU  - Naruse Y
AD  - Cardiovascular Division, Institute of Clinical Medicine, Graduate School of 
      Comprehensive Human Sciences, University of 1-1-1 Tennodai, Tsukuba, Ibaraki 
      305-8575, Japan.
FAU - Sato, Akira
AU  - Sato A
FAU - Kasahara, Kazuyuki
AU  - Kasahara K
FAU - Makino, Kiwa
AU  - Makino K
FAU - Sano, Makoto
AU  - Sano M
FAU - Takeuchi, Yasuyo
AU  - Takeuchi Y
FAU - Nagasaka, Shiro
AU  - Nagasaka S
FAU - Wakabayashi, Yasushi
AU  - Wakabayashi Y
FAU - Katoh, Hideki
AU  - Katoh H
FAU - Satoh, Hiroshi
AU  - Satoh H
FAU - Hayashi, Hideharu
AU  - Hayashi H
FAU - Aonuma, Kazutaka
AU  - Aonuma K
LA  - eng
PT  - Journal Article
DEP - 20111029
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Contrast Media
MH  - Coronary Angiography
MH  - Electrocardiography
MH  - Female
MH  - *Gadolinium DTPA
MH  - Heart Conduction System/physiopathology
MH  - Humans
MH  - Japan
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Takotsubo Cardiomyopathy/*diagnosis/physiopathology
MH  - Time Factors
MH  - Ventricular Function, Left
PMC - PMC3215669
EDAT- 2011/11/01 06:00
MHDA- 2012/03/02 06:00
PMCR- 2011/10/29
CRDT- 2011/11/01 06:00
PHST- 2011/06/05 00:00 [received]
PHST- 2011/10/29 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PHST- 2011/10/29 00:00 [pmc-release]
AID - S1097-6647(23)01422-9 [pii]
AID - 1532-429X-13-67 [pii]
AID - 10.1186/1532-429X-13-67 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2011 Oct 29;13(1):67. doi: 10.1186/1532-429X-13-67.