PMID- 22036600
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20111205
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 12
IP  - 10
DP  - 2011 Dec
TI  - Familial aggregation of narcolepsy.
PG  - 947-51
LID - 10.1016/j.sleep.2011.05.007 [doi]
AB  - OBJECTIVES: To determine the familial aggregation of narcolepsy from perspectives 
      of clinical symptomatology, polysomnographic data, and human leukocyte antigen 
      (HLA) typing. METHODS: This was a Family study at the University-affiliated 
      hospital. The participants were narcolepsy probands and their first degree 
      relatives, and, also, age and sex matched unrelated healthy controls. 
      Interventions were not applicable. MEASUREMENTS AND RESULTS: All study subjects 
      underwent structured interviews, overnight polysomnography followed by a multiple 
      sleep latency test (MSLT), and HLA typing. Altogether, 33 probands and 81 first 
      degree relatives (response rate 65%) were recruited. Among the relatives, 12.3% 
      were diagnosed with narcolepsy and 39.5% had narcolepsy spectrum as defined by 
      unexplained abnormal MSLT (shortened MSL and SOREMP) results. The relative risk 
      of narcolepsy in first degree relatives was 361.8. Familial aggregation of 
      narcolepsy symptoms, excessive daytime sleepiness, HLA status, abnormal MSLT, and 
      nocturnal polysomnographic findings were observed. CONCLUSIONS: The familial risk 
      of narcolepsy among first degree relatives is much higher than previously 
      reported. There exists a spectrum of narcolepsy features among relatives, ranging 
      from full clinical tetrads to asymptomatic abnormal MSLT findings.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Wing, Yun-Kwok
AU  - Wing YK
AD  - Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong. 
      ykwing@cuhk.edu.hk
FAU - Chen, Lei
AU  - Chen L
FAU - Lam, Siu-Ping
AU  - Lam SP
FAU - Li, Albert M
AU  - Li AM
FAU - Tang, Nelson L S
AU  - Tang NL
FAU - Ng, Margaret H L
AU  - Ng MH
FAU - Cheng, Suk-Hang
AU  - Cheng SH
FAU - Ho, Crover K W
AU  - Ho CK
FAU - Mok, V
AU  - Mok V
FAU - Leung, Ho-Wan
AU  - Leung HW
FAU - Lau, Alexander
AU  - Lau A
FAU - Chan, Michael Ho-Ming
AU  - Chan MH
FAU - Chan, Hiu-Shuen
AU  - Chan HS
FAU - Chan, Paul S K
AU  - Chan PS
LA  - eng
PT  - Journal Article
DEP - 20111028
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Family
MH  - Family Health/*statistics & numerical data
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Narcolepsy/diagnosis/*epidemiology/*genetics
MH  - Polysomnography
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
EDAT- 2011/11/01 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/01/05 00:00 [received]
PHST- 2011/03/12 00:00 [revised]
PHST- 2011/05/04 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1389-9457(11)00264-4 [pii]
AID - 10.1016/j.sleep.2011.05.007 [doi]
PST - ppublish
SO  - Sleep Med. 2011 Dec;12(10):947-51. doi: 10.1016/j.sleep.2011.05.007. Epub 2011 
      Oct 28.