PMID- 22037198
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20161125
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 105
IP  - 3
DP  - 2012 Feb 1
TI  - Prenatal stress produces sex differences in nest odor preference.
PG  - 850-5
LID - 10.1016/j.physbeh.2011.10.012 [doi]
AB  - Prenatal stress (PS) and early postnatal environment may alter maternal care. 
      Infant rats learn to identify their mother through the association between 
      maternal care and familiar odors. Female Wistar rats were exposed to restraint 
      stress for 30 min, 4 sessions per day, in the last 7 days of pregnancy. At birth, 
      pups were cross-fostered and assigned to the following groups: prenatal 
      non-stressed mothers raising non-stressed pups (NS:NS), prenatal stressed mothers 
      raising non-stressed pups (S:NS), prenatal non-stressed mothers raising stressed 
      pups (NS:S), prenatal stressed mothers raising stressed pups (S:S). Maternal 
      behaviors were assessed during 6 postpartum days. On postnatal day (PND) 7, the 
      behavior of male and female pups was analyzed in the odor preference test; and 
      noradrenaline (NA) activity in olfactory bulb (OB) was measured. The results 
      showed that restraint stress increased plasma levels of corticosterone on 
      gestational day 15. After parturition, PS reduced maternal care, decreasing 
      licking the pups and increasing frequency outside the nest. Female pups from the 
      NS:S, S:NS, S:S groups and male pups from the S:S group showed no nest odor 
      preference. Thus, at day 7, female pups that were submitted to perinatal 
      interventions showed more impairment in the nest odor preference test than male 
      pups. No changes were detected in the NA activity in the OB. In conclusion, 
      repeated restraint stress during the last week of gestation reduces maternal care 
      and reduces preference for a familiar odor in rat pups in a sex-specific manner.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - de Souza, Marcelo Alves
AU  - de Souza MA
AD  - Departamento de Fisiologia, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul, Sarmento Leite, 500, Porto Alegre, RS, CEP 
      90050-170, Brazil. tiflosoles@yahoo.com.br
FAU - Szawka, Raphael Escorsim
AU  - Szawka RE
FAU - Centenaro, Ligia Aline
AU  - Centenaro LA
FAU - Diehl, Luisa Amalia
AU  - Diehl LA
FAU - Lucion, Aldo Bolten
AU  - Lucion AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111020
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - W980KJ009P (Corticosterone)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - *Behavior, Animal
MH  - Chromatography, High Pressure Liquid
MH  - Corticosterone/blood
MH  - Electrochemistry
MH  - Female
MH  - Humans
MH  - Male
MH  - Maternal Behavior/psychology
MH  - Methoxyhydroxyphenylglycol/metabolism
MH  - Motor Activity
MH  - Norepinephrine
MH  - *Odorants
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Restraint, Physical/methods
MH  - *Sex Characteristics
MH  - Smell/*physiology
MH  - Stress, Psychological/blood/*etiology/psychology
EDAT- 2011/11/01 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/10/12 00:00 [revised]
PHST- 2011/10/13 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - S0031-9384(11)00489-6 [pii]
AID - 10.1016/j.physbeh.2011.10.012 [doi]
PST - ppublish
SO  - Physiol Behav. 2012 Feb 1;105(3):850-5. doi: 10.1016/j.physbeh.2011.10.012. Epub 
      2011 Oct 20.