PMID- 22038257
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20220316
IS  - 1437-7799 (Electronic)
IS  - 1342-1751 (Linking)
VI  - 16
IP  - 1
DP  - 2012 Feb
TI  - The role of the kidney in salt-sensitive hypertension.
PG  - 68-72
LID - 10.1007/s10157-011-0489-y [doi]
AB  - Primary hypertension is one of the leading risk factors for cardiovascular 
      disease. Although the pathogenesis is not completely understood, an imbalance of 
      sodium and chloride homeostasis seems to be relevant both in the induction and in 
      the maintenance of salt-sensitive hypertension. Besides individual renal 
      phenotypes, salt intake is one of the most important environmental determinants 
      of this condition. The Milan hypertensive strain (MHS) of rats is an interesting 
      model to investigate the molecular mechanisms underling the development of 
      salt-sensitive hypertension. In young MHS rats, hypertension is anticipated by a 
      phase of increased salt reabsorption localized along the medullary thick 
      ascending limb associated with the up-regulation of the apical 
      sodium-potassium-chloride cotransporter (NKCC2). Later, the frank hypertensive 
      status of adult MHS rats is accompanied by the activation of the luminal and 
      basal lateral transporters of sodium chloride (NaCl) in the distal convoluted 
      tubule (DCT). Several lines of evidence have proven the key role of DCT in the 
      maintenance of hypertension in MHS rats; more importantly, hypertensive patients 
      carrying a mutation of alpha-adducin (resembling the MHS model) have a high 
      sensitivity to thiazides, suggesting that the Na(+)-Cl(-) cotransporter also 
      plays a pivotal role in humans.
FAU - Trepiccione, Francesco
AU  - Trepiccione F
AD  - Chair of Nephrology, Department of Internal Medicine, Faculty of Medicine, Second 
      University of Naples, Padiglione 17 Policlinico Nuovo, Via Pansini 5, 80131, 
      Naples, Italy.
FAU - Zacchia, Miriam
AU  - Zacchia M
FAU - Capasso, Giovambattista
AU  - Capasso G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111101
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
RN  - 0 (Sodium Chloride, Dietary)
RN  - 0 (Sodium-Potassium-Chloride Symporters)
SB  - IM
MH  - Animals
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Hypertension/etiology/*physiopathology
MH  - Kidney/*physiopathology
MH  - Kidney Tubules, Distal/physiopathology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Sodium Chloride, Dietary/*adverse effects
MH  - Sodium-Potassium-Chloride Symporters/metabolism
EDAT- 2011/11/01 06:00
MHDA- 2012/07/10 06:00
CRDT- 2011/11/01 06:00
PHST- 2010/01/14 00:00 [received]
PHST- 2010/04/22 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
AID - 10.1007/s10157-011-0489-y [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2012 Feb;16(1):68-72. doi: 10.1007/s10157-011-0489-y. Epub 2011 
      Nov 1.