PMID- 22039236
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20221207
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 52
IP  - 13
DP  - 2011 Dec 20
TI  - Determinants of quantitative optic nerve measurements using spectral domain 
      optical coherence tomography in a population-based sample of non-glaucomatous 
      subjects.
PG  - 9629-35
LID - 10.1167/iovs.11-7481 [doi]
AB  - PURPOSE: To evaluate the ocular and systemic factors influencing measurements of 
      optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness 
      with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese 
      adults. METHODS: Adults ranging in age from 40 to 80 years were consecutively 
      recruited from the population-based Singapore Chinese Eye Study. A SD-OCT 
      instrument was used to measure ONH and RNFL parameters. A total of 542 eyes from 
      542 non-glaucomatous Chinese subjects were analyzed. Univariable and multiple 
      linear regression analyses were performed to examine the effects of a range of 
      ocular (e.g., intraocular pressure [IOP], axial length [AL], disc area) and 
      systemic (e.g., blood pressure, serum glucose) factors on ONH and RNFL 
      parameters. RESULTS: In multiple regression analyses, neuroretinal rim area was 
      independently associated with age (beta = -0.006, P < 0.001), disc area (beta = 0.183, 
      P < 0.001), IOP (beta = -0.009, P = 0.008), AL (beta = -0.023, P = 0.004), and lens 
      nuclear color (beta = 0.042, P = 0.001). Vertical cup-to-disc ratio was 
      independently correlated with age (beta = 0.003, P < 0.001), disc area (beta = 0.207, P 
      < 0.001), IOP (beta = 0.004, P = 0.014), AL (beta = 0.010, P = 0.008), and lens nuclear 
      color (beta = -0.017, P = 0.006). Average RNFL thickness was independently related 
      to age (beta = -0.204, P = 0.001), disc area (beta = 4.218, P < 0.001), signal strength 
      (beta = 1.348, P < 0.001), and AL (beta = -1.332, P < 0.001). Disc area had the 
      strongest effect on measurements of ONH parameters and RNFL thickness. 
      CONCLUSIONS: In a non-glaucomatous population, optic nerve measurements with 
      SD-OCT vary with disc area, age, IOP, AL, lens nuclear color, and signal 
      strength, but systemic parameters have little influence. This information may be 
      useful for interpretation of SD-OCT measurements.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
FAU - Chen, David
AU  - Chen D
FAU - Wong, Tien Y
AU  - Wong TY
FAU - Tham, Yih Chung
AU  - Tham YC
FAU - Wu, Renyi
AU  - Wu R
FAU - Zheng, Yingfeng
AU  - Zheng Y
FAU - Cheng, Ching Yu
AU  - Cheng CY
FAU - Saw, Seang Mei
AU  - Saw SM
FAU - Baskaran, Mani
AU  - Baskaran M
FAU - Leung, Christopher K
AU  - Leung CK
FAU - Aung, Tin
AU  - Aung T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111220
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Asian People
MH  - Axial Length, Eye/anatomy & histology
MH  - Blood Pressure/physiology
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - *Nerve Fibers
MH  - Optic Disk/*anatomy & histology
MH  - Optic Nerve/*anatomy & histology
MH  - Reference Values
MH  - Retinal Ganglion Cells/*cytology
MH  - Singapore/epidemiology
MH  - *Tomography, Optical Coherence
EDAT- 2011/11/01 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - iovs.11-7481 [pii]
AID - 10.1167/iovs.11-7481 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2011 Dec 20;52(13):9629-35. doi: 10.1167/iovs.11-7481.