PMID- 22040104
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20120224
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 4
IP  - 1
DP  - 2012 Mar
TI  - Effects of incretins on blood pressure: a promising therapy for type 2 diabetes 
      mellitus with hypertension.
PG  - 22-9
LID - 10.1111/j.1753-0407.2011.00167.x [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) has increased markedly 
      worldwide. A recent epidemiological study reported that approximately 63% of T2DM 
      patients also have high blood pressure (>130/80 mmHg), which doubles their risk 
      of cardiac events. Of the medications used to treat T2DM, the incretins are a 
      group of peptides that not only regulate blood glucose effectively and 
      moderately, but also protect patients against cardiovascular events and improve 
      several cardiovascular parameters. Here were review data from preclinical and 
      short- and long-term clinical studies investigating the antihypertensive effects 
      of incretins. We also elucidate four possible mechanisms underlying the 
      antihypertensive effects of incretins. We conclude that incretins can lower blood 
      pressure of T2DM patients, independent of weight loss, and will surely improve 
      the prognosis of these patients.
CI  - (c) 2011 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and 
      Blackwell Publishing Asia Pty Ltd.
FAU - Wang, Bin
AU  - Wang B
AD  - Company 2, Student Brigade, Daping Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Ni, Yinxing
AU  - Ni Y
FAU - Zhong, Jian
AU  - Zhong J
FAU - Sun, Fang
AU  - Sun F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Incretins)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*drug therapy
MH  - Humans
MH  - Hypertension/*drug therapy
MH  - Incretins/pharmacology/*therapeutic use
EDAT- 2011/11/02 06:00
MHDA- 2012/06/15 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1111/j.1753-0407.2011.00167.x [doi]
PST - ppublish
SO  - J Diabetes. 2012 Mar;4(1):22-9. doi: 10.1111/j.1753-0407.2011.00167.x.