PMID- 22040723
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1820
IP  - 8
DP  - 2012 Aug
TI  - Fundamental properties of Ca2+ signals.
PG  - 1185-94
LID - 10.1016/j.bbagen.2011.10.007 [doi]
AB  - BACKGROUND: Ca2+ is a ubiquitous and versatile second messenger that transmits 
      information through changes of the cytosolic Ca2+ concentration. Recent 
      investigations changed basic ideas on the dynamic character of Ca2+ signals and 
      challenge traditional ideas on information transmission. SCOPE OF REVIEW: We 
      present recent findings on key characteristics of the cytosolic Ca2+ dynamics and 
      theoretical concepts that explain the wide range of experimentally observed Ca2+ 
      signals. Further, we relate properties of the dynamical regulation of the 
      cytosolic Ca2+ concentration to ideas about information transmission by 
      stochastic signals. MAJOR CONCLUSIONS: We demonstrate the importance of the 
      hierarchal arrangement of Ca2+ release sites on the emergence of cellular Ca2+ 
      spikes. Stochastic Ca2+ signals are functionally robust and adaptive to changing 
      environmental conditions. Fluctuations of interspike intervals (ISIs) and the 
      moment relation derived from ISI distributions contain information on the channel 
      cluster open probability and on pathway properties. GENERAL SIGNIFICANCE: Robust 
      and reliable signal transduction pathways that entail Ca2+ dynamics are essential 
      for eukaryotic organisms. Moreover, we expect that the design of a stochastic 
      mechanism which provides robustness and adaptivity will be found also in other 
      biological systems. Ca2+ dynamics demonstrate that the fluctuations of cellular 
      signals contain information on molecular behavior. This article is part of a 
      Special Issue entitled Biochemical, biophysical and genetic approaches to 
      intracellular calcium signaling.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Thurley, Kevin
AU  - Thurley K
AD  - Max Delbruck Center for Molecular Medicine, Robert Rossle Str. 10, 13092 Berlin, 
      Germany. kevin.thurley@mdc-berlin.de
FAU - Skupin, Alexander
AU  - Skupin A
FAU - Thul, Rudiger
AU  - Thul R
FAU - Falcke, Martin
AU  - Falcke M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111025
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Calcium Channels)
RN  - 0 (Inositol 1,4,5-Trisphosphate Receptors)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Calcium Channels/metabolism/physiology
MH  - *Calcium Signaling
MH  - Computer Simulation
MH  - Humans
MH  - Inositol 1,4,5-Trisphosphate Receptors/metabolism/physiology
MH  - Models, Biological
MH  - Probability
EDAT- 2011/11/02 06:00
MHDA- 2012/10/26 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/09/12 00:00 [received]
PHST- 2011/10/16 00:00 [revised]
PHST- 2011/10/17 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - S0304-4165(11)00251-0 [pii]
AID - 10.1016/j.bbagen.2011.10.007 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2012 Aug;1820(8):1185-94. doi: 
      10.1016/j.bbagen.2011.10.007. Epub 2011 Oct 25.