PMID- 22043166
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-5488 (Electronic)
IS  - 1389-2029 (Print)
IS  - 1389-2029 (Linking)
VI  - 12
IP  - 3
DP  - 2011 May
TI  - Gene-diet interactions in childhood obesity.
PG  - 180-9
LID - 10.2174/138920211795677903 [doi]
AB  - Childhood overweight and obesity have reached epidemic proportions worldwide, and 
      the increase in weight-associated co-morbidities including premature type 2 
      diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease will soon 
      become major healthcare and economic problems. A number of studies now indicate 
      that the childhood obesity epidemic which has emerged during the past 30 years is 
      a complex multi-factorial disease resulting from interaction of susceptibility 
      genes with an obesogenic environment. This review will focus on gene-diet 
      interactions suspected of having a prominent role in promoting childhood obesity. 
      In particular, the specific genes that will be presented (FTO, MC4R, and NPC1) 
      have recently been associated with childhood obesity through a genome-wide 
      association study (GWAS) and were shown to interact with nutritional components 
      to increase weight gain. Although a fourth gene (APOA2) has not yet been 
      associated with childhood obesity, this review will also present information on 
      what now represents the best characterized gene-diet interaction in promoting 
      weight gain.
FAU - Garver, William S
AU  - Garver WS
AD  - Department of Biochemistry and Molecular Biology, The University of New Mexico 
      Health Sciences Center, Albuquerque, New Mexico, USA.
LA  - eng
GR  - R21 DK071544/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Genomics
JT  - Current genomics
JID - 100960527
PMC - PMC3137003
OTO - NOTNLM
OT  - Adolescent
OT  - childhood
OT  - gene-diet
OT  - high-fat
OT  - nutrition
OT  - obesity
OT  - overweight.
EDAT- 2011/11/02 06:00
MHDA- 2011/11/02 06:01
PMCR- 2011/11/01
CRDT- 2011/11/02 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/02/17 00:00 [revised]
PHST- 2011/02/28 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/11/02 06:01 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - CG-12-180 [pii]
AID - 10.2174/138920211795677903 [doi]
PST - ppublish
SO  - Curr Genomics. 2011 May;12(3):180-9. doi: 10.2174/138920211795677903.