PMID- 22045510
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20130530
IS  - 1573-9686 (Electronic)
IS  - 0090-6964 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Apr
TI  - The role of sugars in dendritic cell trafficking.
PG  - 777-89
LID - 10.1007/s10439-011-0448-5 [doi]
AB  - Dendritic cells (DCs) are crucial components of the immune response, 
      strategically positioned as immune sentinels. Complex trafficking and accurate 
      positioning of DCs are indispensable for both immunity and tolerance. This is 
      particularly evident for their therapeutic application where an unmet clinical 
      need exists for DCs with improved migratory capacity upon adoptive transfer into 
      patients. One critical step that directs the trafficking of DCs throughout the 
      body is their egress from the vasculature, starting with their adhesive 
      interactions with vascular endothelium under shear flow. Both tethering and 
      rolling rely on interactions mediated by specific glycans attached to 
      glycoproteins and glycolipids present on the DC surface. In DCs, surface 
      glycosylation, including the expression of selectin ligands, changes 
      significantly depending on the local microenvironment and the functional state of 
      the cells. These changes have been documented and have potential implications in 
      important cell functions such as migration. In this article, we review the 
      glycobiological aspects in the context of DC interaction with endothelium, and 
      offer insights on how it can be applied to modulate DC applicability in therapy.
FAU - Silva, Zelia
AU  - Silva Z
AD  - CEDOC, Departamento de Imunologia, Faculdade de Ciencias Medicas, Universidade 
      Nova de Lisboa, Lisboa, Portugal.
FAU - Konstantopoulos, Konstantinos
AU  - Konstantopoulos K
FAU - Videira, Paula A
AU  - Videira PA
LA  - eng
GR  - R01 CA101135/CA/NCI NIH HHS/United States
GR  - U54 CA143868/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111102
PL  - United States
TA  - Ann Biomed Eng
JT  - Annals of biomedical engineering
JID - 0361512
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Carbohydrate Metabolism/*physiology
MH  - Dendritic Cells/cytology/*metabolism/transplantation
MH  - Endothelium, Vascular/cytology/*metabolism
MH  - Glycosylation
MH  - Humans
MH  - Transendothelial and Transepithelial Migration/*physiology
EDAT- 2011/11/03 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/08/01 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1007/s10439-011-0448-5 [doi]
PST - ppublish
SO  - Ann Biomed Eng. 2012 Apr;40(4):777-89. doi: 10.1007/s10439-011-0448-5. Epub 2011 
      Nov 2.