PMID- 22045927
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20240109
IS  - 1539-7262 (Electronic)
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 53
IP  - 1
DP  - 2012 Jan
TI  - Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated 
      with variation in body composition and fasting lipid traits in Yup'ik Eskimos.
PG  - 175-84
LID - 10.1194/jlr.P018952 [doi]
AB  - Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid 
      oxidation enzyme, may influence how fatty acid oxidation contributes to obesity 
      and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions 
      between gene variants and diet may influence outcomes. The objective of this 
      study was to test the association of CPT1A variants with body composition and 
      lipids, mediated by consumption of polyunsaturated fatty acids (PUFA). Obesity 
      phenotypes and fasting lipids were measured in a cross-sectional sample of Yup'ik 
      Eskimo individuals (n = 1141) from the Center of Alaska Native Health Research 
      (CANHR) study. Twenty-eight tagging CPT1A SNPs were evaluated with outcomes of 
      interest in regression models accounting for family structure. Several CPT1A 
      polymorphisms were associated with HDL-cholesterol and obesity phenotypes. The 
      P479L (rs80356779) variant was associated with all obesity-related traits and 
      fasting HDL-cholesterol. Interestingly, the association of P479L with 
      HDL-cholesterol was still significant after correcting for body mass index (BMI), 
      percentage body fat (PBF), or waist circumference (WC). Our findings are 
      consistent with the hypothesis that the L479 allele of the CPT1A P479L variant 
      confers a selective advantage that is both cardioprotective (through increased 
      HDL-cholesterol) and associated with reduced adiposity.
FAU - Lemas, Dominick J
AU  - Lemas DJ
AD  - Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775, 
      USA.
FAU - Wiener, Howard W
AU  - Wiener HW
FAU - O'Brien, Diane M
AU  - O'Brien DM
FAU - Hopkins, Scarlett
AU  - Hopkins S
FAU - Stanhope, Kimber L
AU  - Stanhope KL
FAU - Havel, Peter J
AU  - Havel PJ
FAU - Allison, David B
AU  - Allison DB
FAU - Fernandez, Jose R
AU  - Fernandez JR
FAU - Tiwari, Hemant K
AU  - Tiwari HK
FAU - Boyer, Bert B
AU  - Boyer BB
LA  - eng
GR  - P41 RR003655/RR/NCRR NIH HHS/United States
GR  - P20 RR016430/RR/NCRR NIH HHS/United States
GR  - HL-091333/HL/NHLBI NIH HHS/United States
GR  - R01-DK-074842-02S1/DK/NIDDK NIH HHS/United States
GR  - K12 HD051958/HD/NICHD NIH HHS/United States
GR  - S10 RR026723/RR/NCRR NIH HHS/United States
GR  - AT-003545/AT/NCCIH NIH HHS/United States
GR  - P20-RR-016430/RR/NCRR NIH HHS/United States
GR  - P30 DK056336/DK/NIDDK NIH HHS/United States
GR  - R01 HL091333/HL/NHLBI NIH HHS/United States
GR  - R01-DK-74842/DK/NIDDK NIH HHS/United States
GR  - K23 DK097307/DK/NIDDK NIH HHS/United States
GR  - R01 HL075675/HL/NHLBI NIH HHS/United States
GR  - R01 DK074842/DK/NIDDK NIH HHS/United States
GR  - HL-075675/HL/NHLBI NIH HHS/United States
GR  - DK-097307/DK/NIDDK NIH HHS/United States
GR  - RR-03655/RR/NCRR NIH HHS/United States
GR  - P30-DK-056336/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111101
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Fatty Acids, Omega-3)
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Composition/*genetics
MH  - Carnitine O-Palmitoyltransferase/*genetics
MH  - Cholesterol, HDL/blood
MH  - Fatty Acids, Omega-3/blood
MH  - Humans
MH  - Inuit/*genetics
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - Polymorphism, Single Nucleotide
PMC - PMC3243474
EDAT- 2011/11/03 06:00
MHDA- 2012/04/10 06:00
PMCR- 2013/01/01
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S0022-2275(20)40811-9 [pii]
AID - p018952 [pii]
AID - 10.1194/jlr.P018952 [doi]
PST - ppublish
SO  - J Lipid Res. 2012 Jan;53(1):175-84. doi: 10.1194/jlr.P018952. Epub 2011 Nov 1.