PMID- 22047003
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20111124
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 27
IP  - 12
DP  - 2011 Dec
TI  - Insulin analogues: how observational studies provide key insights into management 
      of patients with type 2 diabetes mellitus.
PG  - 2343-55
LID - 10.1185/03007995.2011.630998 [doi]
AB  - OBJECTIVE: The aim of this commentary was to evaluate the current evidence 
      regarding the use of synthetic insulin analogues in the 'real-world' clinic 
      setting for the treatment of type 2 diabetes mellitus (T2DM). METHODS: Relevant 
      publications were searched on PubMed MEDLINE, EMBASE, Cochrane Register of 
      Controlled Trials Google Scholar, NLM Gateway, Science Direct, Web of Science and 
      OVID for the period of January 2007 to June 2010. Articles were included if they 
      (a) provided specific study results on the use of insulin analogues in T2DM and 
      (b) gave sufficiently clear methodology details to establish treatment 
      strategies, diagnosis and diagnostic criteria using an observational study (OS) 
      design. RESULTS: Twenty one articles specifically addressing both type 2 diabetes 
      management and the use of synthetic insulin analogues were identified. Results 
      from recently published OS in patients with T2DM have shown, in the patient 
      populations tested, the effective initiation, optimization and switch to use of 
      insulin analogues in routine clinical settings (day-to-day common practice), with 
      a good safety profile. CONCLUSIONS: OS can provide clinicians with additional 
      insights into the management of T2DM patients in their practices. However, the 
      selection and initiation of insulin analogue regimens should be tailored to the 
      individual patient and be one that the physician is comfortable using.
FAU - Ligthelm, Robert J
AU  - Ligthelm RJ
AD  - EHM Clinic, Hoofddorp, The Netherlands. rjligthe@xs4all.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111116
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/*analogs & derivatives/*therapeutic use
MH  - Male
MH  - Practice Guidelines as Topic
MH  - PubMed
EDAT- 2011/11/04 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - 10.1185/03007995.2011.630998 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2011 Dec;27(12):2343-55. doi: 10.1185/03007995.2011.630998. 
      Epub 2011 Nov 16.