PMID- 22047537
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20111223
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 45
IP  - 24
DP  - 2011 Dec 15
TI  - Associations between levels of serum perfluorinated chemicals and adiponectin in 
      a young hypertension cohort in Taiwan.
PG  - 10691-8
LID - 10.1021/es201964x [doi]
AB  - In animals, perfluorinated chemicals (PFCs), specifically perfluorooctanoic acid 
      (PFOA) and perfluorooctane sulfate (PFOS), function as peroxisome 
      proliferator-activated receptor (PPAR) alpha agonists. However, the relevance of 
      animal (primarily rodent) data to humans is unresolved. While plasma adiponectin 
      level is very responsive to PPAR gamma agonist drugs, it has not been determined 
      whether adiponectin level is related to serum PFCs concentrations. In the present 
      study, 287 subjects (12-30 years of age) were recruited to determine the 
      relationship between serum level of PFCs and serum level of adiponectin. The 
      results showed males had higher serum PFOS concentrations than females and that 
      those with metabolic syndrome had lower serum PFOA than controls. Besides, it 
      showed regional elevations of the perfluoroundecanoic acid (PFUA) (median 
      concentration: 7.11 ng/mL) in the study subjects. No relationship of PFOA, PFOS, 
      PFUA, and the sum of all four PFCs was found to glucose homeostasis, adiponectin 
      level, lipid profile, and inflammatory markers. The median and the range of 
      perfluorononanoic acid (PFNA) concentration (in ng/mL; for four categories 
      corresponding to the <50, 50-74, 75-89, and >/=90th percentiles) were 0.38 
      (0.38-1.68), 3.22 (1.73-4.65), 5.85 (4.75-8.29), 10.56 (8.40-25.40), 
      respectively. After controlling for confounding factors, multiple linear 
      regression analysis revealed that the mean natural log-transformed level of 
      adiponectin increased significantly across categories of PFNA (in ng/mL; 8.78, 
      8.73, 9.06, 9.36; P for trend = 0.010 in the full model). In conclusion, higher 
      serum PFNA concentration is associated with elevated serum adiponectin 
      concentration.
FAU - Lin, Chien-Yu
AU  - Lin CY
AD  - Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, 
      Taiwan.
FAU - Wen, Li Li
AU  - Wen LL
FAU - Lin, Lian-Yu
AU  - Lin LY
FAU - Wen, Ting-Wen
AU  - Wen TW
FAU - Lien, Guang-Wen
AU  - Lien GW
FAU - Chen, Chia-Yang
AU  - Chen CY
FAU - Hsu, Sandy H J
AU  - Hsu SH
FAU - Chien, Kuo-Liong
AU  - Chien KL
FAU - Sung, Fung-Chang
AU  - Sung FC
FAU - Chen, Pau-Chung
AU  - Chen PC
FAU - Su, Ta-Chen
AU  - Su TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111117
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Adiponectin)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cohort Studies
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Hypertension/*blood/epidemiology
MH  - Male
MH  - Taiwan
MH  - Young Adult
EDAT- 2011/11/04 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - 10.1021/es201964x [doi]
PST - ppublish
SO  - Environ Sci Technol. 2011 Dec 15;45(24):10691-8. doi: 10.1021/es201964x. Epub 
      2011 Nov 17.