PMID- 22047952
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20220408
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 23
IP  - 1
DP  - 2012 Jan
TI  - Sex hormone-binding globulin and type 2 diabetes mellitus.
PG  - 32-40
LID - 10.1016/j.tem.2011.09.005 [doi]
AB  - Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic 
      and environmental factors that potentially contribute to the pathophysiology of 
      type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies 
      demonstrating a consistent relationship between decreased levels of serum SHBG 
      and incident T2DM, recent genetic studies also reveal that transmission of 
      specific polymorphisms in the SHBG gene influence the risk of T2DM. At the 
      molecular level, the multiple interactions between SHBG and its receptors in 
      various target tissues suggest physiologic roles for SHBG that are more complex 
      than the simple transport of sex hormones in serum. Taken together, these data 
      provide support for an expanded role of SHBG in the pathophysiology of insulin 
      resistance and T2DM.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Le, Trang N
AU  - Le TN
AD  - Department of Pediatrics, School of Medicine, Virginia Commonwealth University, 
      Richmond, VA 23298, USA.
FAU - Nestler, John E
AU  - Nestler JE
FAU - Strauss, Jerome F 3rd
AU  - Strauss JF 3rd
FAU - Wickham, Edmond P 3rd
AU  - Wickham EP 3rd
LA  - eng
GR  - K23-HD049454/HD/NICHD NIH HHS/United States
GR  - UL1-RR031990/RR/NCRR NIH HHS/United States
GR  - U54 HD034449/HD/NICHD NIH HHS/United States
GR  - K23 HD053742/HD/NICHD NIH HHS/United States
GR  - UL1 RR031990/RR/NCRR NIH HHS/United States
GR  - K23 HD053742-03/HD/NICHD NIH HHS/United States
GR  - U54 HD034449-15/HD/NICHD NIH HHS/United States
GR  - K24 HD040237-08/HD/NICHD NIH HHS/United States
GR  - K24 HD040237/HD/NICHD NIH HHS/United States
GR  - K23 HD049454/HD/NICHD NIH HHS/United States
GR  - K24-HD40237/HD/NICHD NIH HHS/United States
GR  - UL1 RR031990-02/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20111101
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 0 (sex hormone-binding globulin receptor)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/blood/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Insulin Resistance
MH  - Polymorphism, Genetic
MH  - Receptors, Cell Surface/metabolism
MH  - Sex Hormone-Binding Globulin/analysis/chemistry/genetics/*physiology
PMC - PMC3351377
MID - NIHMS336259
COIS- Potential Conflicts of Interest: None to disclose.
EDAT- 2011/11/04 06:00
MHDA- 2012/04/27 06:00
PMCR- 2013/01/01
CRDT- 2011/11/04 06:00
PHST- 2011/06/01 00:00 [received]
PHST- 2011/09/12 00:00 [revised]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S1043-2760(11)00153-6 [pii]
AID - 10.1016/j.tem.2011.09.005 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2012 Jan;23(1):32-40. doi: 10.1016/j.tem.2011.09.005. 
      Epub 2011 Nov 1.