PMID- 22048047
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20211020
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 160
IP  - 3
DP  - 2012 Mar
TI  - Correlation of N-terminal fragment of B-type natriuretic peptide levels with 
      clinical, laboratory, and echocardiographic abnormalities in children with sickle 
      cell disease.
PG  - 428-433.e1
LID - 10.1016/j.jpeds.2011.09.015 [doi]
AB  - OBJECTIVE: To determine whether the N-terminal fragment of B-type natriuretic 
      peptide (NTproBNP) was a biomarker of clinical, laboratory, and echocardiographic 
      abnormalities in children with homozygous sickle cell disease. STUDY DESIGN: We 
      conducted a single-center retrospective study that consisted of analysis of data 
      from November 2007 to December 2010. We correlated serum NTproBNP with clinical 
      and laboratory findings, echocardiographic data, and New York Heart Association 
      (NYHA) functional class. RESULTS: NTproBNP levels from 42 children (median age, 9 
      years; 52% female) had significant correlations with hemoglobin (r = -0.63, P < 
      .05), and echocardiographic measurements including tricuspid regurgitant velocity 
      (r = 0.46, P < .05), lateral E' (r = -0.52, P < .05), and lateral E/E' ratio (r = 
      0.60, P < .05), suggesting diastolic dysfunction. In addition, NTproBNP levels 
      increased from NYHA functional class I to class III and had a significant linear 
      correlation with the NYHA functional class (r = 0.69, P < .05). CONCLUSIONS: 
      NTproBNP correlated with low hemoglobin and tissue Doppler data as indicators of 
      diastolic dysfunction. Elevated NTproBNP may be a prognostic biomarker for the 
      presence of diastolic dysfunction related to anemia in children with sickle cell 
      disease.
CI  - Copyright A(c) 2012 Mosby, Inc. All rights reserved.
FAU - Takatsuki, Shinichi
AU  - Takatsuki S
AD  - Department of Pediatrics, Section of Pediatric Cardiology, University of Colorado 
      Denver School of Medicine, Children's Hospital of Colorado, Aurora, CO 80045, 
      USA. tekeshin0621@msn.com
FAU - Ivy, David Dunbar
AU  - Ivy DD
FAU - Nuss, Rachelle
AU  - Nuss R
LA  - eng
GR  - UL1 RR025780/RR/NCRR NIH HHS/United States
GR  - M01 RR000069/RR/NCRR NIH HHS/United States
GR  - UL1 RR025780-04/RR/NCRR NIH HHS/United States
GR  - M01 RR000069-45/RR/NCRR NIH HHS/United States
GR  - M01-RR00069/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111101
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Biomarkers)
RN  - 0 (Hemoglobins)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
EIN - J Pediatr. 2012 Mar;160(3):533
MH  - Adolescent
MH  - Anemia, Sickle Cell/blood/complications/*diagnosis/physiopathology
MH  - Biomarkers/blood
MH  - Blood Flow Velocity
MH  - Child
MH  - Child, Preschool
MH  - *Echocardiography
MH  - Female
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Tricuspid Valve Insufficiency/complications/diagnostic imaging/physiopathology
MH  - Young Adult
PMC - PMC3274616
MID - NIHMS324397
COIS- The authors declare no conflicts of interest.
EDAT- 2011/11/04 06:00
MHDA- 2012/03/28 06:00
PMCR- 2013/03/01
CRDT- 2011/11/04 06:00
PHST- 2011/03/25 00:00 [received]
PHST- 2011/07/26 00:00 [revised]
PHST- 2011/09/07 00:00 [accepted]
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - S0022-3476(11)00929-2 [pii]
AID - 10.1016/j.jpeds.2011.09.015 [doi]
PST - ppublish
SO  - J Pediatr. 2012 Mar;160(3):428-433.e1. doi: 10.1016/j.jpeds.2011.09.015. Epub 
      2011 Nov 1.